2-[((4-(N-benzyloxycarbonyl-amino)-phenyl)(methoxy)-phosphinoyl)-methyl]pentane-1,5-dioic acid di-tert-butyl ester

Base Information

Chemical Name:2-[((4-(N-benzyloxycarbonyl-amino)-phenyl)(methoxy)-phosphinoyl)-methyl]pentane-1,5-dioic acid di-tert-butyl ester
CAS No.:947171-08-6
Molecular Formula:C₂₉H₄₀NO₈P
Molecular Weight:561.612
Hs Code.:

Synonyms:2-[((4-(N-benzyloxycarbonyl-amino)-phenyl)(methoxy)-phosphinoyl)-methyl]pentane-1,5-dioic acid di-tert-butyl ester

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Chemical Property of 2-[((4-(N-benzyloxycarbonyl-amino)-phenyl)(methoxy)-phosphinoyl)-methyl]pentane-1,5-dioic acid di-tert-butyl ester

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Technology Process of 2-[((4-(N-benzyloxycarbonyl-amino)-phenyl)(methoxy)-phosphinoyl)-methyl]pentane-1,5-dioic acid di-tert-butyl ester

There total 4 articles about 2-[((4-(N-benzyloxycarbonyl-amino)-phenyl)(methoxy)-phosphinoyl)-methyl]pentane-1,5-dioic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 947171-03-1
(4-(N-benzyloxycarbonylamino)phenyl)phosphinic acid methyl ester

: 125010-32-4
2-methylenepentanedioic acid di-tert-butyl ester

: 947171-08-6
2-[((4-(N-benzyloxycarbonyl-amino)-phenyl)(methoxy)-phosphinoyl)-methyl]pentane-1,5-dioic acid di-tert-butyl ester

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; for 4h;
DOI:10.1021/jo0707840

Reference yield:

: 93298-14-7
(4-iodophenyl)carbamic acid phenylmethyl ester

: 947171-08-6
2-[((4-(N-benzyloxycarbonyl-amino)-phenyl)(methoxy)-phosphinoyl)-methyl]pentane-1,5-dioic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / DABCO; anilinium hypophosphite; 1,3-bis(diphenylphosphino)propane / palladium acetate / acetonitrile / 2 h / 85 °C

2: 57 percent / potassium tert-butoxide / tetrahydrofuran / 4 h / 0 - 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; anilinium hypophosphorous salt; 1,3-bis-(diphenylphosphino)propane; potassium tert-butylate; palladium diacetate; In tetrahydrofuran; acetonitrile; 2: Michaelis-Becker reaction;
DOI:10.1021/jo0707840

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 947171-08-6
2-[((4-(N-benzyloxycarbonyl-amino)-phenyl)(methoxy)-phosphinoyl)-methyl]pentane-1,5-dioic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / tetrahydrofuran / 20 h / 20 °C

2: 71 percent / DABCO; anilinium hypophosphite; 1,3-bis(diphenylphosphino)propane / palladium acetate / acetonitrile / 2 h / 85 °C

3: 57 percent / potassium tert-butoxide / tetrahydrofuran / 4 h / 0 - 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; anilinium hypophosphorous salt; 1,3-bis-(diphenylphosphino)propane; potassium tert-butylate; palladium diacetate; In tetrahydrofuran; acetonitrile; 3: Michaelis-Becker reaction;
DOI:10.1021/jo0707840