2-[((4-amino-phenyl)(methoxy)-phosphinoyl)-methyl]pentane-1,5-dioic acid di-tert-butyl ester

Base Information

• Chemical Name: 2-[((4-amino-phenyl)(methoxy)-phosphinoyl)-methyl]pentane-1,5-dioic acid di-tert-butyl ester
• CAS No.: 947171-13-3
• Molecular Formula: C₂₁H₃₄NO₆P
• Molecular Weight: 427.478
• Mol file: 947171-13-3.mol

Synonyms:2-[((4-amino-phenyl)(methoxy)-phosphinoyl)-methyl]pentane-1,5-dioic acid di-tert-butyl ester

Chemical Property of 2-[((4-amino-phenyl)(methoxy)-phosphinoyl)-methyl]pentane-1,5-dioic acid di-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[((4-amino-phenyl)(methoxy)-phosphinoyl)-methyl]pentane-1,5-dioic acid di-tert-butyl ester

There total 5 articles about 2-[((4-amino-phenyl)(methoxy)-phosphinoyl)-methyl]pentane-1,5-dioic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-[((4-(N-benzyloxycarbonyl-amino)-phenyl)(methoxy)-phosphinoyl)-methyl]pentane-1,5-dioic acid di-tert-butyl ester (947171-08-6) → 2-[((4-amino-phenyl)(methoxy)-phosphinoyl)-methyl]pentane-1,5-dioic acid di-tert-butyl ester (947171-13-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; for 24h;

DOI:10.1021/jo0707840

Reference yield:

(4-(N-benzyloxycarbonylamino)phenyl)phosphinic acid methyl ester (947171-03-1) → 2-[((4-amino-phenyl)(methoxy)-phosphinoyl)-methyl]pentane-1,5-dioic acid di-tert-butyl ester (947171-13-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / potassium tert-butoxide / tetrahydrofuran / 4 h / 0 - 20 °C

2: 89 percent / H₂ / Pd/C / tetrahydrofuran / 24 h

With potassium tert-butylate; hydrogen; palladium on activated charcoal; In tetrahydrofuran; 1: Michaelis-Becker reaction;

DOI:10.1021/jo0707840

Reference yield:

2-methylenepentanedioic acid di-tert-butyl ester (125010-32-4) → 2-[((4-amino-phenyl)(methoxy)-phosphinoyl)-methyl]pentane-1,5-dioic acid di-tert-butyl ester (947171-13-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / potassium tert-butoxide / tetrahydrofuran / 4 h / 0 - 20 °C

2: 89 percent / H₂ / Pd/C / tetrahydrofuran / 24 h

With potassium tert-butylate; hydrogen; palladium on activated charcoal; In tetrahydrofuran; 1: Michaelis-Becker reaction;

DOI:10.1021/jo0707840

upstream raw materials:

2-[((4-(N-benzyloxycarbonyl-amino)-phenyl)(methoxy)-phosphinoyl)-methyl]pentane-1,5-dioic acid di-tert-butyl ester

(4-(N-benzyloxycarbonylamino)phenyl)phosphinic acid methyl ester

2-methylenepentanedioic acid di-tert-butyl ester

(4-iodophenyl)carbamic acid phenylmethyl ester

Downstream raw materials:

C₃₃H₄₇N₆O₈P