5-(difluoromethoxy)-3-(1-phenyl-1H-pyrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

Base Information

Chemical Name:5-(difluoromethoxy)-3-(1-phenyl-1H-pyrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one
CAS No.:1238695-71-0
Molecular Formula:C₂₁H₁₃F₅N₄O₂
Molecular Weight:448.352
Hs Code.:

Synonyms:5-(difluoromethoxy)-3-(1-phenyl-1H-pyrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

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Chemical Property of 5-(difluoromethoxy)-3-(1-phenyl-1H-pyrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

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Technology Process of 5-(difluoromethoxy)-3-(1-phenyl-1H-pyrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

There total 8 articles about 5-(difluoromethoxy)-3-(1-phenyl-1H-pyrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1238695-60-7
5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

: 1895-39-2
sodium chlorodifluoroacetate

: 1238695-71-0
5-(difluoromethoxy)-3-(1-phenyl-1H-pyrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 6h;

Reference yield:

: 98-16-8
3-trifluoromethylaniline

: 1238695-71-0
5-(difluoromethoxy)-3-(1-phenyl-1H-pyrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium nitrite; hydrogenchloride / water / 0.25 h / 0 °C

1.2: 0 °C

2.1: 4 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine; trimethylaluminum / toluene; dichloromethane / 1 h / 0 °C / Inert atmosphere

3.2: 1 h / 0 °C / Inert atmosphere

4.1: tetrahydrofuran; diethyl ether / 1 h / -78 °C

5.1: 3 h / Reflux

6.1: acetic acid / 2 h / Reflux

7.1: chloro-trimethyl-silane; sodium iodide / acetonitrile / 1.5 h / Reflux

8.1: potassium carbonate / water; N,N-dimethyl-formamide / 6 h / 100 °C

With hydrogenchloride; chloro-trimethyl-silane; trimethylaluminum; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium iodide; sodium nitrite; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 4.1: |Grignard Reaction;
DOI:10.1021/jm5013648

Reference yield:

: 1238695-51-6
5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

: 1238695-71-0
5-(difluoromethoxy)-3-(1-phenyl-1H-pyrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: chloro-trimethyl-silane; sodium iodide / acetonitrile / 1.5 h / Reflux

2: potassium carbonate / water; N,N-dimethyl-formamide / 6 h / 100 °C

With chloro-trimethyl-silane; potassium carbonate; sodium iodide; In water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm5013648