methyl 4-methoxy-3-oxo-2-{[3-(trifluoromethyl)phenyl]hydrazono}butanoate

Base Information

Chemical Name:methyl 4-methoxy-3-oxo-2-{[3-(trifluoromethyl)phenyl]hydrazono}butanoate
CAS No.:1238701-59-1
Molecular Formula:C₁₃H₁₃F₃N₂O₄
Molecular Weight:318.252
Hs Code.:

Synonyms:methyl 4-methoxy-3-oxo-2-{[3-(trifluoromethyl)phenyl]hydrazono}butanoate

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Chemical Property of methyl 4-methoxy-3-oxo-2-{[3-(trifluoromethyl)phenyl]hydrazono}butanoate

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Technology Process of methyl 4-methoxy-3-oxo-2-{[3-(trifluoromethyl)phenyl]hydrazono}butanoate

There total 1 articles about methyl 4-methoxy-3-oxo-2-{[3-(trifluoromethyl)phenyl]hydrazono}butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 41051-15-4
4-methoxyacetoacetic acid methylester

: 98-16-8
3-trifluoromethylaniline

: 1238701-59-1
methyl 4-methoxy-3-oxo-2-{[3-(trifluoromethyl)phenyl]hydrazono}butanoate

Guidance literature:: 3-trifluoromethylaniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃;

4-methoxyacetoacetic acid methylester; With sodium acetate; In ethanol; water; at 10 - 35 ℃;

Reference yield: 89.0%

: 1238701-59-1
methyl 4-methoxy-3-oxo-2-{[3-(trifluoromethyl)phenyl]hydrazono}butanoate

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1238701-62-6
methyl 5-methoxy-4-oxo-1-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridazine-3-carboxylate

Guidance literature:: for 4h; Reflux;

Reference yield:

: 1238701-59-1
methyl 4-methoxy-3-oxo-2-{[3-(trifluoromethyl)phenyl]hydrazono}butanoate

: 1238701-64-8
N,5-dimethoxy-N-methyl-4-oxo-1-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridazine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine; trimethylaluminum / toluene; dichloromethane / 1 h / 0 °C / Inert atmosphere

2.2: 1 h / 0 °C / Inert atmosphere

With trimethylaluminum; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene;
DOI:10.1021/jm5013648