benzyl (1-(5-(4-((1R,2S)-1-((bis(benzyloxy)phosphoryl)oxy)-2-(2,2-difluoroacetamido)-3-fluoropropyl)phenyl)pyridin-2-yl)ethyl)carbamate

Base Information

Chemical Name:benzyl (1-(5-(4-((1R,2S)-1-((bis(benzyloxy)phosphoryl)oxy)-2-(2,2-difluoroacetamido)-3-fluoropropyl)phenyl)pyridin-2-yl)ethyl)carbamate
CAS No.:1454908-09-8
Molecular Formula:C₄₀H₃₉F₃N₃O₇P
Molecular Weight:761.735
Hs Code.:

Synonyms:benzyl (1-(5-(4-((1R,2S)-1-((bis(benzyloxy)phosphoryl)oxy)-2-(2,2-difluoroacetamido)-3-fluoropropyl)phenyl)pyridin-2-yl)ethyl)carbamate

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Chemical Property of benzyl (1-(5-(4-((1R,2S)-1-((bis(benzyloxy)phosphoryl)oxy)-2-(2,2-difluoroacetamido)-3-fluoropropyl)phenyl)pyridin-2-yl)ethyl)carbamate

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Technology Process of benzyl (1-(5-(4-((1R,2S)-1-((bis(benzyloxy)phosphoryl)oxy)-2-(2,2-difluoroacetamido)-3-fluoropropyl)phenyl)pyridin-2-yl)ethyl)carbamate

There total 8 articles about benzyl (1-(5-(4-((1R,2S)-1-((bis(benzyloxy)phosphoryl)oxy)-2-(2,2-difluoroacetamido)-3-fluoropropyl)phenyl)pyridin-2-yl)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31181-90-5
5-bromo-pyridine-2-carbaldehyde

: 1454908-09-8
benzyl (1-(5-(4-((1R,2S)-1-((bis(benzyloxy)phosphoryl)oxy)-2-(2,2-difluoroacetamido)-3-fluoropropyl)phenyl)pyridin-2-yl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -20 °C

1.2: -70 - 20 °C

1.3: 20 °C

2.1: sodium hydroxide / water; dichloromethane / 4 h / 0 °C

3.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 80 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 8 h / 0 - 20 °C

5.1: pyridine; trifluoroacetic acid / tetrahydrofuran / 1 h / 0 - 20 °C

5.2: 1 h / 20 °C

With pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; trifluoroacetic acid; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1454908-06-5
benzyl (1-(5-bromopyridin-2-yl)ethyl)carbamate

: 1454908-09-8
benzyl (1-(5-(4-((1R,2S)-1-((bis(benzyloxy)phosphoryl)oxy)-2-(2,2-difluoroacetamido)-3-fluoropropyl)phenyl)pyridin-2-yl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 80 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 8 h / 0 - 20 °C

3.1: pyridine; trifluoroacetic acid / tetrahydrofuran / 1 h / 0 - 20 °C

3.2: 1 h / 20 °C

With pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1454908-07-6
benzyl (1-(5-(4-((4S,5R)-3-(2,2-difluoroacetyl)-4-(fluoromethyl)-2,2-dimethyloxazolidin-5-yl)phenyl)pyridin-2-yl)ethyl)carbamate

: 1454908-09-8
benzyl (1-(5-(4-((1R,2S)-1-((bis(benzyloxy)phosphoryl)oxy)-2-(2,2-difluoroacetamido)-3-fluoropropyl)phenyl)pyridin-2-yl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 8 h / 0 - 20 °C

2.1: pyridine; trifluoroacetic acid / tetrahydrofuran / 1 h / 0 - 20 °C

2.2: 1 h / 20 °C

With pyridine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;