(1R,2S)-1-(4-(6-(1-aminoethyl)pyridin-3-yl)phenyl)-2-(2,2-difluoroacetamido)-3-fluoropropyl dihydrogen phosphate

Base Information

Chemical Name:(1R,2S)-1-(4-(6-(1-aminoethyl)pyridin-3-yl)phenyl)-2-(2,2-difluoroacetamido)-3-fluoropropyl dihydrogen phosphate
CAS No.:1454906-44-5
Molecular Formula:C₁₈H₂₁F₃N₃O₅P
Molecular Weight:447.351
Hs Code.:

Synonyms:(1R,2S)-1-(4-(6-(1-aminoethyl)pyridin-3-yl)phenyl)-2-(2,2-difluoroacetamido)-3-fluoropropyl dihydrogen phosphate

Suppliers and Price of (1R,2S)-1-(4-(6-(1-aminoethyl)pyridin-3-yl)phenyl)-2-(2,2-difluoroacetamido)-3-fluoropropyl dihydrogen phosphate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2S)-1-(4-(6-(1-aminoethyl)pyridin-3-yl)phenyl)-2-(2,2-difluoroacetamido)-3-fluoropropyl dihydrogen phosphate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (1R,2S)-1-(4-(6-(1-aminoethyl)pyridin-3-yl)phenyl)-2-(2,2-difluoroacetamido)-3-fluoropropyl dihydrogen phosphate

There total 10 articles about (1R,2S)-1-(4-(6-(1-aminoethyl)pyridin-3-yl)phenyl)-2-(2,2-difluoroacetamido)-3-fluoropropyl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454908-09-8
benzyl (1-(5-(4-((1R,2S)-1-((bis(benzyloxy)phosphoryl)oxy)-2-(2,2-difluoroacetamido)-3-fluoropropyl)phenyl)pyridin-2-yl)ethyl)carbamate

: 1454906-44-5
(1R,2S)-1-(4-(6-(1-aminoethyl)pyridin-3-yl)phenyl)-2-(2,2-difluoroacetamido)-3-fluoropropyl dihydrogen phosphate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; water; for 5h;

Reference yield:

: 31181-90-5
5-bromo-pyridine-2-carbaldehyde

: 1454906-44-5
(1R,2S)-1-(4-(6-(1-aminoethyl)pyridin-3-yl)phenyl)-2-(2,2-difluoroacetamido)-3-fluoropropyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -20 °C

1.2: -70 - 20 °C

1.3: 20 °C

2.1: sodium hydroxide / water; dichloromethane / 4 h / 0 °C

3.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 80 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 8 h / 0 - 20 °C

5.1: pyridine; trifluoroacetic acid / tetrahydrofuran / 1 h / 0 - 20 °C

5.2: 1 h / 20 °C

6.1: palladium 10% on activated carbon; hydrogen / water; ethanol / 5 h

With pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; sodium carbonate; trifluoroacetic acid; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;

Reference yield:

: 1454908-06-5
benzyl (1-(5-bromopyridin-2-yl)ethyl)carbamate

: 1454906-44-5
(1R,2S)-1-(4-(6-(1-aminoethyl)pyridin-3-yl)phenyl)-2-(2,2-difluoroacetamido)-3-fluoropropyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 80 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 8 h / 0 - 20 °C

3.1: pyridine; trifluoroacetic acid / tetrahydrofuran / 1 h / 0 - 20 °C

3.2: 1 h / 20 °C

4.1: palladium 10% on activated carbon; hydrogen / water; ethanol / 5 h

With pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; sodium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;