Technology Process of 4-benzyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine hydrochloride
There total 5 articles about 4-benzyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: hydrogenchloride / 70 °C
2.1: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / tetrachloromethane / Reflux
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 5 °C
3.2: 20 °C
4.1: water; sodium hydroxide / methanol / 3 h / 50 °C
4.2: 20 °C / pH 3
5.1: hydrogenchloride / 1,4-dioxane / 20 °C
6.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 0 - 20 °C
7.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Reflux
7.2: 5 °C
8.1: hydrogenchloride / ethyl acetate / 0.17 h / 20 °C
With
hydrogenchloride; N-Bromosuccinimide; lithium aluminium tetrahydride; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
2,2'-azobis(isobutyronitrile);
In
tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; ethyl acetate; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / tetrachloromethane / Reflux
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 5 °C
2.2: 20 °C
3.1: water; sodium hydroxide / methanol / 3 h / 50 °C
3.2: 20 °C / pH 3
4.1: hydrogenchloride / 1,4-dioxane / 20 °C
5.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 0 - 20 °C
6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Reflux
6.2: 5 °C
7.1: hydrogenchloride / ethyl acetate / 0.17 h / 20 °C
With
hydrogenchloride; N-Bromosuccinimide; lithium aluminium tetrahydride; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
2,2'-azobis(isobutyronitrile);
In
tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; ethyl acetate; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 5 °C
1.2: 20 °C
2.1: water; sodium hydroxide / methanol / 3 h / 50 °C
2.2: 20 °C / pH 3
3.1: hydrogenchloride / 1,4-dioxane / 20 °C
4.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 0 - 20 °C
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Reflux
5.2: 5 °C
6.1: hydrogenchloride / ethyl acetate / 0.17 h / 20 °C
With
hydrogenchloride; lithium aluminium tetrahydride; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethyl acetate; acetonitrile; mineral oil;
