4-benzyl-5-(2-methoxyphenylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

Base Information

Chemical Name:4-benzyl-5-(2-methoxyphenylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine
CAS No.:1333114-00-3
Molecular Formula:C₂₄H₂₅NO₄S
Molecular Weight:423.533
Hs Code.:

Synonyms:4-benzyl-5-(2-methoxyphenylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

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Chemical Property of 4-benzyl-5-(2-methoxyphenylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

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Technology Process of 4-benzyl-5-(2-methoxyphenylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

There total 7 articles about 4-benzyl-5-(2-methoxyphenylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1333113-98-6
4-benzyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine hydrochloride

: 10130-87-7
o-Methoxybenzenesulfonyl chloride

: 1333114-00-3
4-benzyl-5-(2-methoxyphenylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 118-90-1
ortho-methylbenzoic acid

: 1333114-00-3
4-benzyl-5-(2-methoxyphenylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogenchloride / 70 °C

2.1: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / tetrachloromethane / Reflux

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 5 °C

3.2: 20 °C

4.1: water; sodium hydroxide / methanol / 3 h / 50 °C

4.2: 20 °C / pH 3

5.1: hydrogenchloride / 1,4-dioxane / 20 °C

6.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 0 - 20 °C

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Reflux

7.2: 5 °C

8.1: hydrogenchloride / ethyl acetate / 0.17 h / 20 °C

9.1: triethylamine / dichloromethane / 20 °C

With hydrogenchloride; N-Bromosuccinimide; lithium aluminium tetrahydride; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; dichloromethane; ethyl acetate; acetonitrile; mineral oil;

Reference yield:

: 89-71-4
2-Methyl-benzoic acid methyl ester

: 1333114-00-3
4-benzyl-5-(2-methoxyphenylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / tetrachloromethane / Reflux

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 5 °C

2.2: 20 °C

3.1: water; sodium hydroxide / methanol / 3 h / 50 °C

3.2: 20 °C / pH 3

4.1: hydrogenchloride / 1,4-dioxane / 20 °C

5.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 0 - 20 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Reflux

6.2: 5 °C

7.1: hydrogenchloride / ethyl acetate / 0.17 h / 20 °C

8.1: triethylamine / dichloromethane / 20 °C

With hydrogenchloride; N-Bromosuccinimide; lithium aluminium tetrahydride; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; dichloromethane; ethyl acetate; acetonitrile; mineral oil;