N₂-[4-cyclopropyl-3-(5-(trifluoromethyl)-1H-tetrazol-1-yl)phenyl]-5-fluoro-N₄-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidine-2,4-diamine

Base Information

• Chemical Name: N₂-[4-cyclopropyl-3-(5-(trifluoromethyl)-1H-tetrazol-1-yl)phenyl]-5-fluoro-N₄-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidine-2,4-diamine
• CAS No.: 1356493-37-2
• Molecular Formula: C₂₄H₂₉F₄N₉
• Molecular Weight: 519.548

Synonyms:N₂-[4-cyclopropyl-3-(5-(trifluoromethyl)-1H-tetrazol-1-yl)phenyl]-5-fluoro-N₄-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidine-2,4-diamine

Chemical Property of N₂-[4-cyclopropyl-3-(5-(trifluoromethyl)-1H-tetrazol-1-yl)phenyl]-5-fluoro-N₄-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidine-2,4-diamine

Chemical Property:

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Technology Process of N₂-[4-cyclopropyl-3-(5-(trifluoromethyl)-1H-tetrazol-1-yl)phenyl]-5-fluoro-N₄-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidine-2,4-diamine

There total 6 articles about N₂-[4-cyclopropyl-3-(5-(trifluoromethyl)-1H-tetrazol-1-yl)phenyl]-5-fluoro-N₄-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

2-chloro-5-fluoro-N4-(2,2,6,6-tetramethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride + 4-cyclopropyl-3-(5-(trifluoromethyl)-1H-tetrazol-1-yl)benzenamine (1356493-64-5) → N2-[4-cyclopropyl-3-(5-(trifluoromethyl)-1H-tetrazol-1-yl)phenyl]-5-fluoro-N4-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidine-2,4-diamine (1356493-37-2)

Guidance literature:

2-chloro-5-fluoro-N₄-(2,2,6,6-tetramethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride; 4-cyclopropyl-3-(5-(trifluoromethyl)-1H-tetrazol-1-yl)benzenamine; With toluene-4-sulfonic acid; In isopropyl alcohol; at 100 ℃;

With ammonia; In methanol; isopropyl alcohol; at 20 ℃;

Reference yield:

2-bromo 5-nitroaniline (10403-47-1) → N2-[4-cyclopropyl-3-(5-(trifluoromethyl)-1H-tetrazol-1-yl)phenyl]-5-fluoro-N4-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidine-2,4-diamine (1356493-37-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: tricyclohexylphosphine; caesium carbonate / palladium diacetate / toluene; water / 12 h / Inert atmosphere; Reflux

2.1: triethylamine; triphenylphosphine; tetrachloromethane / 0.17 h / 0 °C

2.2: 12 h / Reflux

3.1: sodium azide / acetonitrile / 16 h / 20 °C

4.1: ammonium chloride / iron / ethanol; water / 1 h / Reflux

5.1: toluene-4-sulfonic acid / isopropyl alcohol / 100 °C

5.2: 20 °C

With tetrachloromethane; sodium azide; ammonium chloride; caesium carbonate; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; tricyclohexylphosphine; palladium diacetate; iron; In ethanol; water; isopropyl alcohol; toluene; acetonitrile;

Reference yield:

2-cyclopropyl-5-nitroaniline (1239596-36-1) → N2-[4-cyclopropyl-3-(5-(trifluoromethyl)-1H-tetrazol-1-yl)phenyl]-5-fluoro-N4-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidine-2,4-diamine (1356493-37-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triethylamine; triphenylphosphine; tetrachloromethane / 0.17 h / 0 °C

1.2: 12 h / Reflux

2.1: sodium azide / acetonitrile / 16 h / 20 °C

3.1: ammonium chloride / iron / ethanol; water / 1 h / Reflux

4.1: toluene-4-sulfonic acid / isopropyl alcohol / 100 °C

4.2: 20 °C

With tetrachloromethane; sodium azide; ammonium chloride; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; iron; In ethanol; water; isopropyl alcohol; acetonitrile;

upstream raw materials:

4-AMINO-2,2,6,6-TETRAMETHYLPIPERIDINE

2-bromo 5-nitroaniline

2-cyclopropyl-5-nitroaniline

4-cyclopropyl-3-(5-(trifluoromethyl)-1H-tetrazol-1-yl)benzenamine

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