4-Amino-2,2,6,6-tetramethylpiperidine

Base Information

• Chemical Name: 4-Amino-2,2,6,6-tetramethylpiperidine
• CAS No.: 36768-62-4
• Deprecated CAS: 118326-87-7,2434633-51-7
• Molecular Formula: C9H20N2
• Molecular Weight: 156.271
• Hs Code.: 29333999
• European Community (EC) Number: 253-197-2
• NSC Number: 102510
• UNII: ETF220Q65R
• DSSTox Substance ID: DTXSID3044388
• Nikkaji Number: J111.335F
• Wikipedia: 4-Amino-2,2,6,6-tetramethylpiperidine
• Wikidata: Q27277360
• ChEMBL ID: CHEMBL368366
• Mol file: 36768-62-4.mol

Synonyms:4-amino-2,2,6,6-tetramethylpiperidine;4-amino-2,2,6,6-TMP

Chemical Property of 4-Amino-2,2,6,6-tetramethylpiperidine

Chemical Property:

• Appearance/Colour: Clear, slightly yellow liquid
• Vapor Pressure: 0.597mmHg at 25°C
• Melting Point: 16-18 °C(lit.)
• Refractive Index: n20/D 1.470(lit.)
• Boiling Point: 188.5 °C at 760 mmHg
• PKA: 10.83±0.10(Predicted)
• Flash Point: 72.2 °C
• PSA: 38.05000
• Density: 0.836 g/cm³
• LogP: 2.28340
• Storage Temp.: Store below +30°C.
• Water Solubility.: soluble
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 156.162648646
• Heavy Atom Count: 11
• Complexity: 134

Purity/Quality:

99.0% ^*data from raw suppliers

4-Amino-2,2,6,6-tetramethylpiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi, C
• Hazard Codes: Xn,Xi,C
• Statements: 22-36/37/38-34-52/53-41
• Safety Statements: 26-36/37-45-36/37/39-61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CC(CC(N1)(C)C)N)C
• Uses: Triacetonediamine have been investigated as new anticancer drugs with high activity and low toxicity. Additive for light and heat stability of polyamide 6 containing hindered piperidine amines and tertiary aminesTemplate for preparation of ammoniopiperidinium hydrogen phosphatesFiber-reactive yellowing inhibitor for partial brightness stabilization of peroxide-bleached pulpsReactant for thermostability of soybean / sunflower oils

Technology Process of 4-Amino-2,2,6,6-tetramethylpiperidine

There total 17 articles about 4-Amino-2,2,6,6-tetramethylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-hydroxyimino-2,2,6,6-tetramethylpiperidine (4168-79-0) → 4-AMINO-2,2,6,6-TETRAMETHYLPIPERIDINE (36768-62-4)

Guidance literature:

With sulfuric acid; electrochemical, Pb cathode; i=400 mA/cm²;

Reference yield: 95.5%

C9H18N2 → 4-AMINO-2,2,6,6-TETRAMETHYLPIPERIDINE (36768-62-4)

Guidance literature:

With ammonium formate; at 190 ℃; for 2h; under 22502.3 Torr; Temperature; Pressure; Reagent/catalyst;

Reference yield: 94.7%

2,2,6,6-Tetramethyl-4-piperidone (826-36-8) → 4-AMINO-2,2,6,6-TETRAMETHYLPIPERIDINE (36768-62-4)

Guidance literature:

With ammonium formate; at 200 ℃; for 6h; Temperature;

upstream raw materials:

2,2,6,6-Tetramethyl-4-piperidone

4-hydroxyimino-2,2,6,6-tetramethylpiperidine

2,2,6,6-tetramethyl-4-oxopiperidine hydrazone

2,2,6,6,-tetramethyl-4-oxo-piperidine azine

Downstream raw materials:

4-hydroxy-2,2,6,6-tetramethylpiperidine

N-[2,2,6,6-tetramethyl-4-piperidinyl]benzamide

5-(2-Aminopyrimidin-4-yl)-4-(4-fluorophenyl)-1-(2,2,6,6-tetramethylpiperidin-4-yl)imidazole

1-(2,2,6,6-tetramethyl-4-piperidinyl)-4-(4-fluorophenyl)-5-acetylimidazole

Refernces

• 1、 -. "Catalyst-free method for synthesizing 2, 2, 6, 6-tetramethyl-4-piperidylamine". Paragraph 0023-0039. . Retrieved 2021/05/01.
• 2、 -. "Synthetic method of amino-2,2,6,6-tetramentylniperidine with specific pH range". Paragraph 0025; 0038-0073. . Retrieved 2019/07/04.