Technology Process of N-acetyl-4-(o-bromophenyl)butylamine
There total 6 articles about N-acetyl-4-(o-bromophenyl)butylamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 81 percent / sodium bicarbonate, tetra-n-butyl ammonium chloride, palladium acetate / dimethylformamide / 18.5 h / 40 °C
2: 78 percent / NaBH4 / methanol / a) RT, 14 h, b) reflux, 3.5 h
3: 91 percent / pyridine / 0 °C
4: 62 percent / tetrahydrofuran; dimethylsulfoxide / 6 h / 65 °C
5: 75 percent / LiAlH4, AlCl3 / diethyl ether / 11 h
6: 81 percent / Et3N / CH2Cl2 / 2 h
With
pyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; aluminium trichloride; tetrabutyl-ammonium chloride; palladium diacetate; sodium hydrogencarbonate; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(96)00266-9
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 91 percent / pyridine / 0 °C
2: 62 percent / tetrahydrofuran; dimethylsulfoxide / 6 h / 65 °C
3: 75 percent / LiAlH4, AlCl3 / diethyl ether / 11 h
4: 81 percent / Et3N / CH2Cl2 / 2 h
With
pyridine; lithium aluminium tetrahydride; aluminium trichloride; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/0040-4020(96)00266-9
