1,3,5-triisopropyl-cyclohexane-1,3,5-tricarboxylic acid trimethyl ester

Base Information

• Chemical Name: 1,3,5-triisopropyl-cyclohexane-1,3,5-tricarboxylic acid trimethyl ester
• CAS No.: 253200-54-3
• Molecular Formula: C₂₁H₃₆O₆
• Molecular Weight: 384.513
• Mol file: 253200-54-3.mol

Synonyms:1,3,5-triisopropyl-cyclohexane-1,3,5-tricarboxylic acid trimethyl ester

Chemical Property of 1,3,5-triisopropyl-cyclohexane-1,3,5-tricarboxylic acid trimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3,5-triisopropyl-cyclohexane-1,3,5-tricarboxylic acid trimethyl ester

There total 1 articles about 1,3,5-triisopropyl-cyclohexane-1,3,5-tricarboxylic acid trimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2-iodo-propane (75-30-9) + trimethyl cis,cis-cyclohexane-1,3,5-tricarboxylate (6998-83-0) → 1,3,5-triisopropyl-cyclohexane-1,3,5-tricarboxylic acid trimethyl ester (253200-54-3)

Guidance literature:

trimethyl cis,cis-cyclohexane-1,3,5-tricarboxylate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at 0 ℃; for 2h;

2-iodo-propane; With N,N,N,N,N,N-hexamethylphosphoric triamide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 24h;

DOI:10.1246/bcsj.72.2337

Reference yield:

1,3,5-triisopropyl-cyclohexane-1,3,5-tricarboxylic acid trimethyl ester (253200-54-3) → 1,3,5-triisopropyl-cyclohexane-1,3,5-tricarboxylic acid

Guidance literature:

With lithium iodide; In pyridine; for 64h; Heating;

DOI:10.1246/bcsj.72.2337

Reference yield:

1,3,5-triisopropyl-cyclohexane-1,3,5-tricarboxylic acid trimethyl ester (253200-54-3) → (1R,5S,7R)-1,5,7-Triisopropyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid ((R)-1-cyclohexyl-ethyl)-amide

Guidance literature:

Multi-step reaction with 4 steps

1: LiI / pyridine / 64 h / Heating

2: bis-(2-methoxy-ethyl) ether / 4 h / 170 - 180 °C

3: 754 mg / SOCl₂ / 3 h / 110 °C

4: 833 mg / Et₃N; 4-dimethylaminopyridine / CH₂Cl₂ / 12 h / 20 °C

With dmap; thionyl chloride; triethylamine; lithium iodide; In pyridine; dichloromethane; diethylene glycol dimethyl ether; 1: Substitution / 2: Cyclization / 3: Chlorination / 4: Acylation;

DOI:10.1246/bcsj.72.2337

upstream raw materials:

2-iodo-propane

trimethyl cis,cis-cyclohexane-1,3,5-tricarboxylate