(S)-2-Benzyl-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid 4-nitro-phenyl ester

Base Information

Chemical Name:(S)-2-Benzyl-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid 4-nitro-phenyl ester
CAS No.:204187-34-8
Molecular Formula:C₂₅H₂₈N₂O₅
Molecular Weight:436.508
Hs Code.:

Synonyms:(S)-2-Benzyl-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid 4-nitro-phenyl ester

Suppliers and Price of (S)-2-Benzyl-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid 4-nitro-phenyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (S)-2-Benzyl-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid 4-nitro-phenyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-2-Benzyl-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid 4-nitro-phenyl ester

There total 3 articles about (S)-2-Benzyl-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid 4-nitro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1470-99-1,1220913-24-5
cis-hexahydroisoindoline

: 157060-06-5
(S)-2-Benzyl-succinic acid bis-(4-nitro-phenyl) ester

: 204187-34-8
(S)-2-Benzyl-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid 4-nitro-phenyl ester

Guidance literature:: In dichloromethane; at 0 - 20 ℃;
DOI:10.1248/cpb.46.337

Reference yield:

: 36092-42-9,884-33-3
2-benzylsuccinic acid

: 204187-34-8
(S)-2-Benzyl-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

2: 1.) SOCl₂, Et₃N / 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) CH₂Cl₂, RT, overnight

3: 80 percent / CH₂Cl₂ / 0 - 20 °C

With thionyl chloride; triethylamine; In dichloromethane;
DOI:10.1248/cpb.46.337

Reference yield:

: 3972-36-9,884-33-3
(2S)-benzylsuccinic acid

: 204187-34-8
(S)-2-Benzyl-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) SOCl₂, Et₃N / 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) CH₂Cl₂, RT, overnight

2: 80 percent / CH₂Cl₂ / 0 - 20 °C

With thionyl chloride; triethylamine; In dichloromethane;
DOI:10.1248/cpb.46.337