DL-BENZYLSUCCINIC ACID

Base Information

• Chemical Name: DL-BENZYLSUCCINIC ACID
• CAS No.: 36092-42-9
• Molecular Formula: C11H12O4
• Molecular Weight: 208.214
• Mol file: 36092-42-9.mol

Synonyms:2-Benzylsuccinic acid;

Chemical Property of DL-BENZYLSUCCINIC ACID

Chemical Property:

• Appearance/Colour: Off-White Solid
• Vapor Pressure: 6.23E-05mmHg at 25°C
• Melting Point: 160-161°C
• Refractive Index: 1.567
• Boiling Point: 331.4 °C at 760 mmHg
• PKA: pK1: 4.11;pK2: 5.65 (20°C)
• Flash Point: 168.4 °C
• PSA: 74.60000
• Density: 1.29 g/cm³
• LogP: 1.40460
• Storage Temp.: -20°C Freezer

Purity/Quality:

99%min ^*data from raw suppliers

D,L-BENZYLSUCCINIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An effective inhibitor of carboxypeptidase A

Technology Process of DL-BENZYLSUCCINIC ACID

There total 46 articles about DL-BENZYLSUCCINIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(Z)-2-benzylidenesuccinic acid (65756-81-2) → 2-benzylsuccinic acid (36092-42-9,884-33-3)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; at 75 ℃; for 3h;

DOI:10.1016/S0957-4166(02)00822-4

Reference yield: 95.0%

3-benzyl-4-(tert-butoxy)-4-oxobutanoic acid (125470-05-5) → 2-benzylsuccinic acid (36092-42-9,884-33-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1055/s-2000-7110

Reference yield: 90.0%

maleic anhydride (108-31-6) + benzyltrimethylsilane (770-09-2) → 2-benzylsuccinic acid (36092-42-9,884-33-3)

Guidance literature:

With tetrabutylammonium decatungstate; In acetonitrile; for 24h; Inert atmosphere; Irradiation;

DOI:10.1021/ol301900p

upstream raw materials:

3-phenyl-propane-1,2,2-tricarboxylic acid

2-Benzyl-4-oxopentanoic acid

trans-phenylitaconic acid

benzylmaleic acid

Downstream raw materials:

dimethyl 2-benzylsuccinate

3-benzyl-1-dodecyl-pyrrolidine-2,5-dione

1,4-diethyl 2-benzylsuccinate

3-benzyl-pyrrolidine-2,5-dione

Refernces

• 1、 Poklukar, Ga?per,Stephan, Michel,Mohar, Barbara. "Modular 1,1′-Ferrocenediyl-cored P-Stereogenic Diphosphines: ′′JDayPhos′′ Series and its Use in Rhodium(I)-Catalyzed Hydrogenation". supporting information. p. 2566 - 2570. Retrieved 2018/05/16.
• 2、 Selvakumar, Jayaraman,Mangalaraj, Selvaraj,Achari, Kamsali Murali Mohan,Mukund, Krishna,Ramanathan, Chinnasamy Ramaraj. "Triflic Acid Mediated Cyclization of Unsymmetrical N -Phenethyl- and N -(3-Indolylethyl)succinimides: Regio- and Diastereoselective Synthesis of Substituted Pyrroloisoquinolinones and Indolizino-indolones". supporting information. p. 1053 - 1064. Retrieved 2017/02/24.