6-benzyl-3-(3-methyl-4-hydroxyphenyl)-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one

Base Information

• Chemical Name: 6-benzyl-3-(3-methyl-4-hydroxyphenyl)-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one
• CAS No.: 1186078-61-4
• Molecular Formula: C₁₉H₁₅N₃O₂S
• Molecular Weight: 349.413
• Mol file: 1186078-61-4.mol

Synonyms:6-benzyl-3-(3-methyl-4-hydroxyphenyl)-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one

Chemical Property of 6-benzyl-3-(3-methyl-4-hydroxyphenyl)-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-benzyl-3-(3-methyl-4-hydroxyphenyl)-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one

There total 5 articles about 6-benzyl-3-(3-methyl-4-hydroxyphenyl)-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.1%

6-(phenylmethyl)-3,4-dihydro-3-thioxo-1,2,4-triazin-5(2H)-one (7338-80-9) + 2-chloro-1-(4-hydroxy-3-methyl-phenyl)-ethanone (40943-24-6) → 6-benzyl-3-(3-methyl-4-hydroxyphenyl)-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one (1186078-61-4)

Guidance literature:

With sodium acetate; acetic acid; for 8h; Reflux;

DOI:10.2174/157018010789869343

Reference yield:

2-(N-acetylamino)cinnamic acid (55065-02-6,64590-80-3,5469-45-4) → 6-benzyl-3-(3-methyl-4-hydroxyphenyl)-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one (1186078-61-4)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / water / 7 h / Reflux

2: potassium carbonate / ethanol; water / 2 h / Reflux

3: sodium acetate / acetic acid / Reflux

With hydrogenchloride; sodium acetate; potassium carbonate; In ethanol; water; acetic acid;

DOI:10.1016/j.ejmech.2014.05.020

Reference yield:

benzaldehyde (100-52-7) → 6-benzyl-3-(3-methyl-4-hydroxyphenyl)-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one (1186078-61-4)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium acetate / acetic anhydride / 7 h / 120 °C

2: water / acetone / 10 h / Reflux

3: hydrogenchloride / water / 7 h / Reflux

4: potassium carbonate / ethanol; water / 2 h / Reflux

5: sodium acetate / acetic acid / Reflux

With hydrogenchloride; water; sodium acetate; potassium carbonate; In ethanol; water; acetic anhydride; acetic acid; acetone;

DOI:10.1016/j.ejmech.2014.05.020

upstream raw materials:

6-(phenylmethyl)-3,4-dihydro-3-thioxo-1,2,4-triazin-5(2H)-one

2-chloro-1-(4-hydroxy-3-methyl-phenyl)-ethanone

benzaldehyde

4-benzylidene-2-methyl-2-oxazolin-5-one