N'-acetyl-N-(3'-monophosphate-2'-deoxyguanosin-8-yl)-4,4'-methylenedianiline

Base Information

Chemical Name:N'-acetyl-N-(3'-monophosphate-2'-deoxyguanosin-8-yl)-4,4'-methylenedianiline
CAS No.:182230-60-0
Molecular Formula:C₂₅H₂₈N₇O₈P
Molecular Weight:585.513
Hs Code.:

Synonyms:N'-acetyl-N-(3'-monophosphate-2'-deoxyguanosin-8-yl)-4,4'-methylenedianiline

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Chemical Property of N'-acetyl-N-(3'-monophosphate-2'-deoxyguanosin-8-yl)-4,4'-methylenedianiline

Chemical Property:

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Technology Process of N'-acetyl-N-(3'-monophosphate-2'-deoxyguanosin-8-yl)-4,4'-methylenedianiline

There total 5 articles about N'-acetyl-N-(3'-monophosphate-2'-deoxyguanosin-8-yl)-4,4'-methylenedianiline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.3%

: 6220-62-8
2'-deoxyguanosine-3'-monophosphate

: 182230-59-7
N-acetoxy-N'acetyl-4,4'-methylenedianiline

: 182230-60-0
N'-acetyl-N-(3'-monophosphate-2'-deoxyguanosin-8-yl)-4,4'-methylenedianiline

Guidance literature:: With triethylamine; In tetrahydrofuran; water; at 37 ℃; for 1.5h;
DOI:10.1021/tx950194+

Reference yield:

: 24367-94-0
N¹-[4-(4-Aminobenzyl)phenyl]acetamide

: 182230-60-0
N'-acetyl-N-(3'-monophosphate-2'-deoxyguanosin-8-yl)-4,4'-methylenedianiline

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / m-CPBA / CH₂Cl₂ / 1 h / 20 °C

2: 95 percent / NH₂NH₂*H₂O / Pd/C (5 percent) / tetrahydrofuran / 1.5 h / 5 °C

3: Et₃N / tetrahydrofuran / 1.5 h / -20 °C

4: 3.3 percent / Et₃N / tetrahydrofuran; H₂O / 1.5 h / 37 °C

With hydrazine hydrate; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; 1: Oxidation / 2: Reduction / 3: Acetylation / 4: Substitution;
DOI:10.1021/tx950194+

Reference yield:

: 6665-60-7
N-acetyl-4′-amino-4-nitrodiphenylmethane

: 182230-60-0
N'-acetyl-N-(3'-monophosphate-2'-deoxyguanosin-8-yl)-4,4'-methylenedianiline

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / NH₂NH₂*H₂O / Pd/C (5 percent) / tetrahydrofuran / 1.5 h / 5 °C

2: Et₃N / tetrahydrofuran / 1.5 h / -20 °C

3: 3.3 percent / Et₃N / tetrahydrofuran; H₂O / 1.5 h / 37 °C

With hydrazine hydrate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; water; 1: Reduction / 2: Acetylation / 3: Substitution;
DOI:10.1021/tx950194+