threo-2-Fluoro-2-phenyl-1-methylethylamine

Base Information

• Chemical Name: threo-2-Fluoro-2-phenyl-1-methylethylamine
• CAS No.: 74275-07-3
• Molecular Formula: C₉H₁₂FN
• Molecular Weight: 153.199
• Mol file: 74275-07-3.mol

Synonyms:threo-2-Fluoro-2-phenyl-1-methylethylamine

Chemical Property of threo-2-Fluoro-2-phenyl-1-methylethylamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of threo-2-Fluoro-2-phenyl-1-methylethylamine

There total 5 articles about threo-2-Fluoro-2-phenyl-1-methylethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(2-Azido-1-fluoro-propyl)-benzene → threo-2-Fluoro-2-phenyl-1-methylethylamine (74275-07-3)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol; for 24h; Ambient temperature;

DOI:10.1016/S0022-1139(00)82016-3

Reference yield: 71.0%

trans-2-Phenyl-3-methylaziridine (20993-60-6) → erythro-2-Fluoro-2-phenyl-1-methylethylamine (75197-98-7) + threo-2-Fluoro-2-phenyl-1-methylethylamine (74275-07-3)

Guidance literature:

With hydrogen fluoride; In pyridine; benzene; for 5h; Product distribution; Mechanism; Ambient temperature; var. of solv., temp., fluoride ion conc.;

DOI:10.1021/jo01314a023

Reference yield: 69.0%

cis-2-Phenyl-3-methylaziridine (1485-13-8) → erythro-2-Fluoro-2-phenyl-1-methylethylamine (75197-98-7) + threo-2-Fluoro-2-phenyl-1-methylethylamine (74275-07-3)

Guidance literature:

With hydrogen fluoride; In pyridine; benzene; at 40 ℃; for 10h; Product distribution; Mechanism; var. of solv., temp., fluoride ion conc.;

DOI:10.1021/jo01314a023

upstream raw materials:

cis-2-Phenyl-3-methylaziridine

trans-2-Phenyl-3-methylaziridine

Downstream raw materials:

threo-N-benzoyl-1-fluoro-1phenyl-2-aminopropane

cis-4-methyl-2,5-diphenyl-2-oxazoline