Technology Process of Boc-Glu(OBzl)-Glu(OH)-Asn-NH2
There total 4 articles about Boc-Glu(OBzl)-Glu(OH)-Asn-NH2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) THF, -15 deg C, 5 min, 2.) -15 deg C, 0.5 h; 25 deg C
2: 96 percent / hydrogen, formic acid / Pd black / methanol / 0.25 h
3: CF3CO2H / CH2Cl2 / 0.5 h / 25 °C
4: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) THF, -15 deg C, 5 min, 2.) -15 deg C, 0.5 h; 25 deg C
With
4-methyl-morpholine; formic acid; hydrogen; trifluoroacetic acid; isobutyl chloroformate;
palladium;
In
methanol; dichloromethane;
DOI:10.1021/ja00414a075
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 96 percent / hydrogen, formic acid / Pd black / methanol / 0.25 h
2: CF3CO2H / CH2Cl2 / 0.5 h / 25 °C
3: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) THF, -15 deg C, 5 min, 2.) -15 deg C, 0.5 h; 25 deg C
With
4-methyl-morpholine; formic acid; hydrogen; trifluoroacetic acid; isobutyl chloroformate;
palladium;
In
methanol; dichloromethane;
DOI:10.1021/ja00414a075
- Guidance literature:
-
Multi-step reaction with 2 steps
1: CF3CO2H / CH2Cl2 / 0.5 h / 25 °C
2: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) THF, -15 deg C, 5 min, 2.) -15 deg C, 0.5 h; 25 deg C
With
4-methyl-morpholine; trifluoroacetic acid; isobutyl chloroformate;
In
dichloromethane;
DOI:10.1021/ja00414a075
