(E)-3-(3-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylic acid trifluoroacetate

Base Information

Chemical Name:(E)-3-(3-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylic acid trifluoroacetate
CAS No.:1123622-41-2
Molecular Formula:C₂HF₃O₂*C₂₃H₂₄N₂O₃
Molecular Weight:490.479
Hs Code.:

Synonyms:(E)-3-(3-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylic acid trifluoroacetate

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Chemical Property of (E)-3-(3-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylic acid trifluoroacetate

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Technology Process of (E)-3-(3-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylic acid trifluoroacetate

There total 6 articles about (E)-3-(3-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 56915-77-6
1-[2-(4-methylpiperazin-1-yl)phenyl]ethanone

: 934622-50-1
tert-butyl (E)-3-(3-formylphenyl)acrylate

: 1123622-41-2
(E)-3-(3-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylic acid trifluoroacetate

Guidance literature:: 1-[2-(4-methylpiperazin-1-yl)phenyl]ethanone; tert-butyl (E)-3-(3-formylphenyl)acrylate; With potassium hydroxide; In ethanol; water; at 20 ℃; for 12h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 6h;

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 1123622-41-2
(E)-3-(3-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate; triethylamine / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 4 h / 100 °C

2.1: potassium hydroxide / ethanol; water / 12 h / 20 °C

2.2: 6 h / 20 °C

With potassium hydroxide; sodium hydrogencarbonate; triethylamine; palladium diacetate; triphenylphosphine; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 394-47-8
2-fluorobenzonitrile

: 1123622-41-2
(E)-3-(3-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / dimethyl sulfoxide / 24 h / 120 °C

2.1: ammonia / water / Alkaline conditions

2.2: 4 h / Heating / reflux

3.1: potassium hydroxide / ethanol; water / 12 h / 20 °C

3.2: 6 h / 20 °C

With potassium hydroxide; ammonia; potassium carbonate; In ethanol; water; dimethyl sulfoxide;