(E)-N-hydroxy-3-(3-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylamide trifluoroacetate

Base Information

Chemical Name:(E)-N-hydroxy-3-(3-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylamide trifluoroacetate
CAS No.:1123622-94-5
Molecular Formula:C₂HF₃O₂*C₂₃H₂₅N₃O₃
Molecular Weight:505.494
Hs Code.:

Synonyms:(E)-N-hydroxy-3-(3-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylamide trifluoroacetate

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Chemical Property of (E)-N-hydroxy-3-(3-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylamide trifluoroacetate

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Technology Process of (E)-N-hydroxy-3-(3-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylamide trifluoroacetate

There total 6 articles about (E)-N-hydroxy-3-(3-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1123622-41-2
(E)-3-(3-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylic acid trifluoroacetate

: 1123622-94-5
(E)-N-hydroxy-3-(3-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylamide trifluoroacetate

Guidance literature:: (E)-3-(3-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylic acid trifluoroacetate; With O-2-tetrahydro-2H-pyranhydroxylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 12h;

With hydrogenchloride; In diethyl ether; dichloromethane; for 2h;

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 1123622-94-5
(E)-N-hydroxy-3-(3-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate; triethylamine / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 4 h / 100 °C

2.1: potassium hydroxide / ethanol; water / 12 h / 20 °C

2.2: 6 h / 20 °C

3.1: O-2-tetrahydro-2H-pyranhydroxylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / tetrahydrofuran; N,N-dimethyl-formamide / 12 h / 20 °C

3.2: 2 h

With potassium hydroxide; O-2-tetrahydro-2H-pyranhydroxylamine; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium diacetate; triphenylphosphine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 394-47-8
2-fluorobenzonitrile

: 1123622-94-5
(E)-N-hydroxy-3-(3-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-phenyl)-acrylamide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / dimethyl sulfoxide / 24 h / 120 °C

2.1: ammonia / water / Alkaline conditions

2.2: 4 h / Heating / reflux

3.1: potassium hydroxide / ethanol; water / 12 h / 20 °C

3.2: 6 h / 20 °C

4.1: O-2-tetrahydro-2H-pyranhydroxylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / tetrahydrofuran; N,N-dimethyl-formamide / 12 h / 20 °C

4.2: 2 h

With potassium hydroxide; O-2-tetrahydro-2H-pyranhydroxylamine; ammonia; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;