N-((6-amino-2-pyridyl)methyl)-N,N-bis((2-pyridyl)methyl)amine

Base Information

• Chemical Name: N-((6-amino-2-pyridyl)methyl)-N,N-bis((2-pyridyl)methyl)amine
• CAS No.: 639009-04-4
• Molecular Formula: C₁₈H₁₉N₅
• Molecular Weight: 305.382
• Mol file: 639009-04-4.mol

Synonyms:N-((6-amino-2-pyridyl)methyl)-N,N-bis((2-pyridyl)methyl)amine

Chemical Property of N-((6-amino-2-pyridyl)methyl)-N,N-bis((2-pyridyl)methyl)amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((6-amino-2-pyridyl)methyl)-N,N-bis((2-pyridyl)methyl)amine

There total 1 articles about N-((6-amino-2-pyridyl)methyl)-N,N-bis((2-pyridyl)methyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloromethylpyridine (4377-33-7) → N-((6-amino-2-pyridyl)methyl)-N,N-bis((2-pyridyl)methyl)amine (639009-04-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 45.9 percent / KOH / dioxane; H₂O / 72 h / 50 °C

2: 70 percent / KOH / ethanol / 168000 h / 50 °C

With potassium hydroxide; In 1,4-dioxane; ethanol; water;

DOI:10.1002/ejic.200300178

Reference yield: 82.0%

zinc perchlorate + diethyl ether (60-29-7,927820-24-4) + acetonitrile (75-05-8,26809-02-9) + N-((6-amino-2-pyridyl)methyl)-N,N-bis((2-pyridyl)methyl)amine (639009-04-4) → [(N-((6-amino-2-pyridyl)methyl)-N,N-bis((2-pyridyl)methyl)amine)ZnOH(acetonitrile)]ClO4*0.25(diethyl ether)

Guidance literature:

With (CH₃)4NOH*5H₂O; In acetonitrile; a soln. of Zn salt added to a soln. of ligand, stirred for 30 min, addedto (CH3)4NOH*5H2O, stirred for 12 h at room temp.; evapd. (vac.), dissolved in CH2Cl2, filtered, evapd. (vac.), dissolved in MeCN, pptd. (Et2O), decanted, dried (vac.); elem. anal.;

DOI:10.1021/ic050750f

Reference yield: 78.0%

perfluorobenzaldehyde (653-37-2) + N-((6-amino-2-pyridyl)methyl)-N,N-bis((2-pyridyl)methyl)amine (639009-04-4) → 6-((bis(pyridin-2-ylmethyl)amino)methyl)-N-((perfluorophenyl)methyl)pyridin-2-amine

Guidance literature:

perfluorobenzaldehyde; N-((6-amino-2-pyridyl)methyl)-N,N-bis((2-pyridyl)methyl)amine; In ethanol; at 20 ℃; for 48h; Inert atmosphere;

In ethanol; at 90 ℃; for 48h; Inert atmosphere;

With sodium tetrahydroborate; In ethanol; for 12h;

DOI:10.1021/jacs.8b04671

upstream raw materials:

2-chloromethylpyridine

Downstream raw materials:

Cu(I)[(6-aminopyrid-2-yl)methyl]bis(pyrid-2-ylmethyl)amine PF₆

[Cu(tris(2-benzylaminoethyl)amine)(CH₃CN)]PF₆

[(tris(3-Ph-pyrazolyl)methane)Cu(acetonitrile)](PF₆)

[(tris(3-Ph-pyrazolyl)methane)Cu(carbonyl)](PF₆)