2-{3-[N'-(6-benzyloxycarbonylamino-2-tert-butoxycarbonylaminohexanoyl)hydrazino]-4,4,4-trifluorobutyrylamino}-3-phenylpropionic acid methyl ester

Base Information

• Chemical Name: 2-{3-[N'-(6-benzyloxycarbonylamino-2-tert-butoxycarbonylaminohexanoyl)hydrazino]-4,4,4-trifluorobutyrylamino}-3-phenylpropionic acid methyl ester
• CAS No.: 1123546-15-5
• Molecular Formula: C₃₃H₄₄F₃N₅O₈
• Molecular Weight: 695.736

Synonyms:2-{3-[N'-(6-benzyloxycarbonylamino-2-tert-butoxycarbonylaminohexanoyl)hydrazino]-4,4,4-trifluorobutyrylamino}-3-phenylpropionic acid methyl ester

Chemical Property of 2-{3-[N'-(6-benzyloxycarbonylamino-2-tert-butoxycarbonylaminohexanoyl)hydrazino]-4,4,4-trifluorobutyrylamino}-3-phenylpropionic acid methyl ester

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Technology Process of 2-{3-[N'-(6-benzyloxycarbonylamino-2-tert-butoxycarbonylaminohexanoyl)hydrazino]-4,4,4-trifluorobutyrylamino}-3-phenylpropionic acid methyl ester

There total 1 articles about 2-{3-[N'-(6-benzyloxycarbonylamino-2-tert-butoxycarbonylaminohexanoyl)hydrazino]-4,4,4-trifluorobutyrylamino}-3-phenylpropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

3-phenyl-2-(4,4,4-trifluoro-3-hydrazinobutyrylamino)propionic acid methyl ester trifluoroacetic acid salt (1123546-32-6) + Boc-Lys(Z)-OH (2389-45-9) → 2-{3-[N'-(6-benzyloxycarbonylamino-2-tert-butoxycarbonylaminohexanoyl)hydrazino]-4,4,4-trifluorobutyrylamino}-3-phenylpropionic acid methyl ester (1123546-15-5)

Guidance literature:

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 68h; Inert atmosphere;

DOI:10.1016/j.bmcl.2008.11.012

Reference yield: 100.0%

2-{3-[N'-(6-benzyloxycarbonylamino-2-tert-butoxycarbonylaminohexanoyl)hydrazino]-4,4,4-trifluorobutyrylamino}-3-phenylpropionic acid methyl ester (1123546-15-5) + trifluoroacetic acid (76-05-1) → C2HF3O2*C28H36F3N5O6

Guidance literature:

In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2008.11.012

Reference yield:

2-{3-[N'-(6-benzyloxycarbonylamino-2-tert-butoxycarbonylaminohexanoyl)hydrazino]-4,4,4-trifluorobutyrylamino}-3-phenylpropionic acid methyl ester (1123546-15-5) → 2-{3-[N'-(6-amino-2-tert-butoxycarbonylaminohexanoyl)hydrazino]-4,4,4-trifluorobutyrylamino}-3-phenylpropionic acid methyl ester (1123546-18-8)

Guidance literature:

With palladium on carbon; hydrogen; In methanol; at 20 ℃; under 760.051 Torr;

DOI:10.1016/j.bmcl.2008.11.012

upstream raw materials:

3-phenyl-2-(4,4,4-trifluoro-3-hydrazinobutyrylamino)propionic acid methyl ester trifluoroacetic acid salt

Boc-Lys(Z)-OH

Downstream raw materials:

2-{3-[N'-(6-amino-2-tert-butoxycarbonylaminohexanoyl)hydrazino]-4,4,4-trifluorobutyrylamino}-3-phenylpropionic acid methyl ester

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