[2-chloro-4-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]dec-8-yl}-3-oxopropyl)phenoxy]acetic acid tert-butyl ester

Base Information

Chemical Name:[2-chloro-4-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]dec-8-yl}-3-oxopropyl)phenoxy]acetic acid tert-butyl ester
CAS No.:1366295-92-2
Molecular Formula:C₂₇H₃₄Cl₂N₈O₅
Molecular Weight:621.524
Hs Code.:

Synonyms:[2-chloro-4-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]dec-8-yl}-3-oxopropyl)phenoxy]acetic acid tert-butyl ester

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Chemical Property of [2-chloro-4-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]dec-8-yl}-3-oxopropyl)phenoxy]acetic acid tert-butyl ester

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Technology Process of [2-chloro-4-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]dec-8-yl}-3-oxopropyl)phenoxy]acetic acid tert-butyl ester

There total 4 articles about [2-chloro-4-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]dec-8-yl}-3-oxopropyl)phenoxy]acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31770-76-0
3-(4-hydroxyphenyl)propionic acid benzyl ester

: 1366295-92-2
[2-chloro-4-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]dec-8-yl}-3-oxopropyl)phenoxy]acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: trichloroisocyanuric acid / acetonitrile / 0 - 20 °C

2: sodium carbonate / N,N-dimethyl-formamide / 60 °C

3: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 3 h / 262.53 Torr

4: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

With 4-methyl-morpholine; trichloroisocyanuric acid; hydrogen; sodium carbonate; HATU; palladium 10% on activated carbon; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1160939-79-6
3,5-diamino-6-chloropyrazine-2-carboxylic acid [1,3,8-triazaspiro[4.5]dec-(2E)-ylidene]amide

: 1366067-35-7
3-(4-tert-butoxycarbonylmethoxy-3-chlorophenyl)propionic acid

: 1366295-92-2
[2-chloro-4-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]dec-8-yl}-3-oxopropyl)phenoxy]acetic acid tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 1366068-27-0
3-(3-chloro-4-hydroxyphenyl)propionic acid benzyl ester

: 1366295-92-2
[2-chloro-4-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]dec-8-yl}-3-oxopropyl)phenoxy]acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / N,N-dimethyl-formamide / 60 °C

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 3 h / 262.53 Torr

3: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

With 4-methyl-morpholine; hydrogen; sodium carbonate; HATU; palladium 10% on activated carbon; In tetrahydrofuran; N,N-dimethyl-formamide;