[2-chloro-4-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]dec-8-yl}-3-oxopropyl)phenoxy]acetic acid dipropylcarbamoylmethyl ester

Base Information

Chemical Name:[2-chloro-4-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]dec-8-yl}-3-oxopropyl)phenoxy]acetic acid dipropylcarbamoylmethyl ester
CAS No.:1366295-75-1
Molecular Formula:C₃₁H₄₁Cl₂N₉O₆
Molecular Weight:706.629
Hs Code.:

[2-chloro-4-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]dec-8-yl}-3-oxopropyl)phenoxy]acetic acid dipropylcarbamoylmethyl ester

Synonyms:[2-chloro-4-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]dec-8-yl}-3-oxopropyl)phenoxy]acetic acid dipropylcarbamoylmethyl ester

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Chemical Property of [2-chloro-4-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]dec-8-yl}-3-oxopropyl)phenoxy]acetic acid dipropylcarbamoylmethyl ester

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Technology Process of [2-chloro-4-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]dec-8-yl}-3-oxopropyl)phenoxy]acetic acid dipropylcarbamoylmethyl ester

There total 7 articles about [2-chloro-4-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]dec-8-yl}-3-oxopropyl)phenoxy]acetic acid dipropylcarbamoylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31770-76-0
3-(4-hydroxyphenyl)propionic acid benzyl ester

: 1366295-75-1
[2-chloro-4-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]dec-8-yl}-3-oxopropyl)phenoxy]acetic acid dipropylcarbamoylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: trichloroisocyanuric acid / acetonitrile / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 60 °C

3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 3 h / 262.53 Torr / Inert atmosphere

4: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

5: hydrogenchloride / 1,4-dioxane / 24 h / 20 °C

6: sodium hydrogencarbonate / N,N-dimethyl-formamide / 60 °C

With 4-methyl-morpholine; hydrogenchloride; trichloroisocyanuric acid; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; potassium carbonate; HATU; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;