3-{[4-({Acetyl-[2-(4-hydroxy-phenyl)-ethyl]-amino}-methyl)-phenyl]-dimethyl-silanyl}-propionic acid methyl ester

Base Information

Chemical Name:3-{[4-({Acetyl-[2-(4-hydroxy-phenyl)-ethyl]-amino}-methyl)-phenyl]-dimethyl-silanyl}-propionic acid methyl ester
CAS No.:195454-15-0
Molecular Formula:C₂₃H₃₁NO₄Si
Molecular Weight:413.589
Hs Code.:

Synonyms:3-{[4-({Acetyl-[2-(4-hydroxy-phenyl)-ethyl]-amino}-methyl)-phenyl]-dimethyl-silanyl}-propionic acid methyl ester

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Chemical Property of 3-{[4-({Acetyl-[2-(4-hydroxy-phenyl)-ethyl]-amino}-methyl)-phenyl]-dimethyl-silanyl}-propionic acid methyl ester

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Technology Process of 3-{[4-({Acetyl-[2-(4-hydroxy-phenyl)-ethyl]-amino}-methyl)-phenyl]-dimethyl-silanyl}-propionic acid methyl ester

There total 7 articles about 3-{[4-({Acetyl-[2-(4-hydroxy-phenyl)-ethyl]-amino}-methyl)-phenyl]-dimethyl-silanyl}-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 108-24-7
acetic anhydride

: 195454-14-9
3-[(4-{[2-(4-Hydroxy-phenyl)-ethylamino]-methyl}-phenyl)-dimethyl-silanyl]-propionic acid methyl ester

: 195454-15-0
3-{[4-({Acetyl-[2-(4-hydroxy-phenyl)-ethyl]-amino}-methyl)-phenyl]-dimethyl-silanyl}-propionic acid methyl ester

Guidance literature:: With pyridine; In dichloromethane; for 16h;
DOI:10.1021/jo9620472

Reference yield:

: 873-75-6
4-bromobenzenemethanol

: 195454-15-0
3-{[4-({Acetyl-[2-(4-hydroxy-phenyl)-ethyl]-amino}-methyl)-phenyl]-dimethyl-silanyl}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 99 percent / imidazole / dimethylformamide / 24 h / Ambient temperature

2: 1.) Mg, 1,2-dibromoethane / 1.) THF, reflux, 5 h, 2.) THF, -78 deg C, 1 h; room temperature, 16 h

3: 70 percent / NaOMe / methanol / 24 h / 70 °C

4: 87 percent / AcOH, H₂O / tetrahydrofuran / 24 h / 45 °C

5: 89 percent / MnO₂ / CH₂Cl₂ / 16 h / Heating

6: 1.) AcOH, 2.) NaBH₃CN / 1.) MeOH, room temperature, 2 h, 2.) 16 h

7: 95 percent / pyridine / CH₂Cl₂ / 16 h

With pyridine; 1H-imidazole; manganese(IV) oxide; water; sodium methylate; sodium cyanoborohydride; magnesium; acetic acid; ethylene dibromide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo9620472

Reference yield:

: 181717-64-6
4-(triisopropylsilyloxymethyl)bromobenzene

: 195454-15-0
3-{[4-({Acetyl-[2-(4-hydroxy-phenyl)-ethyl]-amino}-methyl)-phenyl]-dimethyl-silanyl}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Mg, 1,2-dibromoethane / 1.) THF, reflux, 5 h, 2.) THF, -78 deg C, 1 h; room temperature, 16 h

2: 70 percent / NaOMe / methanol / 24 h / 70 °C

3: 87 percent / AcOH, H₂O / tetrahydrofuran / 24 h / 45 °C

4: 89 percent / MnO₂ / CH₂Cl₂ / 16 h / Heating

5: 1.) AcOH, 2.) NaBH₃CN / 1.) MeOH, room temperature, 2 h, 2.) 16 h

6: 95 percent / pyridine / CH₂Cl₂ / 16 h

With pyridine; manganese(IV) oxide; water; sodium methylate; sodium cyanoborohydride; magnesium; acetic acid; ethylene dibromide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo9620472