Technology Process of Methyl 4,5-O-diacetyl-(-)-shikimate
There total 6 articles about Methyl 4,5-O-diacetyl-(-)-shikimate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 95 percent / Amberlite IR 120 / 12 h / Heating
2: 96 percent / camphorsulfonic acid / 0.25 h / Ambient temperature
3: 100 percent / 4-(dimethylamino)pyridine / CH2Cl2 / 2 h / Ambient temperature
4: 94 percent / aq. HOAc / tetrahydrofuran / 6 h / 70 °C
5: 1.) dibutyltin oxide / 1.) benzene, reflux, 1 h, 2.) DMF, 30 min
6: 100 percent / 4-(dimethylamino)pyridine / CH2Cl2 / 1 h / 50 °C
7: 89 percent / 80percent aq. HOAc / 0.25 h
With
dmap; Amberlite IR 120; di(n-butyl)tin oxide; acetic acid;
camphor-10-sulfonic acid;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00047a049
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 96 percent / camphorsulfonic acid / 0.25 h / Ambient temperature
2: 100 percent / 4-(dimethylamino)pyridine / CH2Cl2 / 2 h / Ambient temperature
3: 94 percent / aq. HOAc / tetrahydrofuran / 6 h / 70 °C
4: 1.) dibutyltin oxide / 1.) benzene, reflux, 1 h, 2.) DMF, 30 min
5: 100 percent / 4-(dimethylamino)pyridine / CH2Cl2 / 1 h / 50 °C
6: 89 percent / 80percent aq. HOAc / 0.25 h
With
dmap; di(n-butyl)tin oxide; acetic acid;
camphor-10-sulfonic acid;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00047a049
