(R)-(4-t-butoxycarbonylamino)butyl p-tolylsulfinylmethyl ketone

Base Information

• Chemical Name: (R)-(4-t-butoxycarbonylamino)butyl p-tolylsulfinylmethyl ketone
• CAS No.: 260561-02-2
• Molecular Formula: C₁₈H₂₇NO₄S
• Molecular Weight: 353.483
• Mol file: 260561-02-2.mol

Synonyms:(R)-(4-t-butoxycarbonylamino)butyl p-tolylsulfinylmethyl ketone

Chemical Property of (R)-(4-t-butoxycarbonylamino)butyl p-tolylsulfinylmethyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(4-t-butoxycarbonylamino)butyl p-tolylsulfinylmethyl ketone

There total 3 articles about (R)-(4-t-butoxycarbonylamino)butyl p-tolylsulfinylmethyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(R)-methyl p-tolyl sulfoxide (1519-39-7) + 2-oxopiperidine-1-carboxylic acid tert-butyl ester (85908-96-9) → (R)-(4-t-butoxycarbonylamino)butyl p-tolylsulfinylmethyl ketone (260561-02-2)

Guidance literature:

(R)-methyl p-tolyl sulfoxide; With lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃; for 0.5h;

2-oxopiperidine-1-carboxylic acid tert-butyl ester; In tetrahydrofuran; at -78 ℃; for 1h;

DOI:10.1016/S0957-4166(99)00523-6

Reference yield:

piperidin-2-one (675-20-7) → (R)-(4-t-butoxycarbonylamino)butyl p-tolylsulfinylmethyl ketone (260561-02-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 48 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 24 h / 20 °C

2.1: LDA / tetrahydrofuran / 0.5 h / 0 °C

2.2: 89 percent / tetrahydrofuran / 1 h / -78 °C

With dmap; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; 1.1: Acylation / 2.1: Metallation / 2.2: Condensation;

DOI:10.1016/S0957-4166(99)00523-6

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (R)-(4-t-butoxycarbonylamino)butyl p-tolylsulfinylmethyl ketone (260561-02-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 48 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 24 h / 20 °C

2.1: LDA / tetrahydrofuran / 0.5 h / 0 °C

2.2: 89 percent / tetrahydrofuran / 1 h / -78 °C

With dmap; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; 1.1: Acylation / 2.1: Metallation / 2.2: Condensation;

DOI:10.1016/S0957-4166(99)00523-6

upstream raw materials:

(R)-methyl p-tolyl sulfoxide

2-oxopiperidine-1-carboxylic acid tert-butyl ester

piperidin-2-one

di-tert-butyl dicarbonate

Downstream raw materials:

(+)-2,3,4,5-Tetrahydro-6-<(R)-(4-methylphenyl)sulfinylmethyl>pyridine