3-Fluoro-2-(trifluoroMethyl)benzeneboronic acid pinacol ester, 96%

Base Information

• Chemical Name: 3-Fluoro-2-(trifluoroMethyl)benzeneboronic acid pinacol ester, 96%
• CAS No.: 1192548-05-2
• Molecular Formula: C₁₃H₁₅BF₄O₂
• Molecular Weight: 290.066
• Mol file: 1192548-05-2.mol

Synonyms:3-fluoro-2-trifluoromethylphenylboronic acid pinacol ester

Chemical Property of 3-Fluoro-2-(trifluoroMethyl)benzeneboronic acid pinacol ester, 96%

Chemical Property:

• Melting Point: 34-36℃
• Boiling Point: 309.2±42.0 °C(Predicted)
• Density: 1.20±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-[3-Fluoro-2-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 3-Fluoro-2-(trifluoroMethyl)benzeneboronic acid pinacol ester, 96%

There total 1 articles about 3-Fluoro-2-(trifluoroMethyl)benzeneboronic acid pinacol ester, 96% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

bis(pinacol)diborane (73183-34-3) + 1-bromo-3-fluoro-2-(trifluoromethyl)benzene (261951-85-3) → 3-fluoro-2-trifluoromethylphenylboronic acid pinacol ester (1192548-05-2)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 110 ℃; for 1h;

Reference yield: 88.0%

3-fluoro-2-trifluoromethylphenylboronic acid pinacol ester (1192548-05-2) + tert-butyl 3-(7-chloro-8-fluoro-2-((tetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)pyrido[4,3-d]pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octane-8-carboxylate → tert-butyl 3-(8-fluoro-7-(3-fluoro-2-(trifluoromethyl)phenyl)-2-((tetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)pyrido[4,3-d]pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:

With potassium phosphate; [(di(1-adamantyl)butylphosphine)-2-(2′-amino-1,1′-biphenyl)]palladium(II) methanesulfonate; In tetrahydrofuran; water; at 60 ℃; for 2h;

Reference yield:

3-fluoro-2-trifluoromethylphenylboronic acid pinacol ester (1192548-05-2) + methyl 4-iodo-3-methylbenzoate (5471-81-8) → methyl 3'-fluoro-2-methyl-2'-(trifluoromethyl)biphenyl-4-carboxylate (1192547-79-7)

Guidance literature:

With potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In water; toluene; at 100 ℃; for 12h;

upstream raw materials:

bis(pinacol)diborane

1-bromo-3-fluoro-2-(trifluoromethyl)benzene

Downstream raw materials:

methyl 3'-fluoro-2-methyl-2'-(trifluoromethyl)biphenyl-4-carboxylate

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