tert-butyl 2-<2-bromo(1-piperidin-1-yl)cyclohexenyl>acetate

Base Information

• Chemical Name: tert-butyl 2-<2-bromo(1-piperidin-1-yl)cyclohexenyl>acetate
• CAS No.: 161295-05-2
• Molecular Formula: C₁₇H₃₀BrNO₂
• Molecular Weight: 360.335
• Mol file: 161295-05-2.mol

Synonyms:tert-butyl 2-<2-bromo(1-piperidin-1-yl)cyclohexenyl>acetate

Chemical Property of tert-butyl 2-<2-bromo(1-piperidin-1-yl)cyclohexenyl>acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of tert-butyl 2-<2-bromo(1-piperidin-1-yl)cyclohexenyl>acetate

There total 1 articles about tert-butyl 2-<2-bromo(1-piperidin-1-yl)cyclohexenyl>acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(cyclohex-1-en-1-yl)piperidine (2981-10-4) + acetic acid tert-butyl ester (540-88-5) → tert-butyl 2-<2-bromo(1-piperidin-1-yl)cyclohexenyl>acetate (161295-05-2)

Guidance literature:

With bromine; lithium diisopropyl amide; Yield given. Multistep reaction; 1.) Et₂O, -78 deg C, 0.5 h; 2.) Et₂O, n-hexane, r.t., 30 min;

DOI:10.1055/s-1994-25716

Reference yield: 95.0%

tert-butyl 2-<2-bromo(1-piperidin-1-yl)cyclohexenyl>acetate (161295-05-2) → tert-butyl 2-<2-(piperidin-1-yl)cyclohex-2-enyl>acetate

Guidance literature:

With potassium tert-butylate; In diethyl ether; for 0.0833333h; Ambient temperature;

DOI:10.1055/s-1994-25716

Reference yield:

tert-butyl 2-<2-bromo(1-piperidin-1-yl)cyclohexenyl>acetate (161295-05-2) → (2-oxocyclohexyl)acetic acid (1438-96-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / potassium tert-butoxide / diethyl ether / 0.08 h / Ambient temperature

2: 75 percent / 2 N aq. HCl / 24 h / Ambient temperature

With hydrogenchloride; potassium tert-butylate; In diethyl ether;

DOI:10.1055/s-1994-25716

upstream raw materials:

1-(cyclohex-1-en-1-yl)piperidine

acetic acid tert-butyl ester

Downstream raw materials:

(2-oxocyclohexyl)acetic acid