1-(4-benzyloxy-3-methoxyphenyl)-3-(2,3-dibenzyloxy-5-dimethoxymethylphenyl)-2-propen-1-one

Base Information

Chemical Name:1-(4-benzyloxy-3-methoxyphenyl)-3-(2,3-dibenzyloxy-5-dimethoxymethylphenyl)-2-propen-1-one
CAS No.:119384-65-5
Molecular Formula:C₄₀H₃₈O₇
Molecular Weight:630.738
Hs Code.:

Synonyms:1-(4-benzyloxy-3-methoxyphenyl)-3-(2,3-dibenzyloxy-5-dimethoxymethylphenyl)-2-propen-1-one

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Chemical Property of 1-(4-benzyloxy-3-methoxyphenyl)-3-(2,3-dibenzyloxy-5-dimethoxymethylphenyl)-2-propen-1-one

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Technology Process of 1-(4-benzyloxy-3-methoxyphenyl)-3-(2,3-dibenzyloxy-5-dimethoxymethylphenyl)-2-propen-1-one

There total 5 articles about 1-(4-benzyloxy-3-methoxyphenyl)-3-(2,3-dibenzyloxy-5-dimethoxymethylphenyl)-2-propen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1835-11-6
4-benzyloxy-3-methoxyacetophenone

: 119384-64-4
3,4-dibenzyloxy-5-formylbenzaldehyde dimethyl acetal

: 119384-65-5
1-(4-benzyloxy-3-methoxyphenyl)-3-(2,3-dibenzyloxy-5-dimethoxymethylphenyl)-2-propen-1-one

Guidance literature:: With potassium hydroxide; In ethanol; for 4h;
DOI:10.1248/cpb.37.1441

Reference yield:

: 119384-63-3
5-bromo-3,4-benzyloxybenzaldehyde dimethyl acetal

: 119384-65-5
1-(4-benzyloxy-3-methoxyphenyl)-3-(2,3-dibenzyloxy-5-dimethoxymethylphenyl)-2-propen-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) Et₂O, -78 deg C, 2.) -78 to r.t.

2: 93 percent / KOH / ethanol

With potassium hydroxide; n-butyllithium; In ethanol;
DOI:10.1039/c39880000749

Reference yield:

: 16414-34-9
3-bromo-4,5-dihydroxybenzaldehyde

: 119384-65-5
1-(4-benzyloxy-3-methoxyphenyl)-3-(2,3-dibenzyloxy-5-dimethoxymethylphenyl)-2-propen-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / potassium carbonate / dimethylformamide / 3 h / Heating

2: 91 percent / ammonium chloride / methanol / 4 h / Heating

3: 94 percent / 1.) n-butyl lithium / hexane; diethyl ether / 1.) -78 deg C, 10 min, 2.) -78 deg C to room temperature, 3 h

4: 93 percent / potassium hydroxide / ethanol / 4 h

With potassium hydroxide; n-butyllithium; ammonium chloride; potassium carbonate; In methanol; diethyl ether; ethanol; hexane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.37.1441