3-hydroxymethyl-2-(4-hydroxy-3-methoxyphenyl)-7-hydroxy-5-acetoxymethyl-2,3-dihydrobenzofuran

Base Information

Chemical Name:3-hydroxymethyl-2-(4-hydroxy-3-methoxyphenyl)-7-hydroxy-5-acetoxymethyl-2,3-dihydrobenzofuran
CAS No.:119384-68-8
Molecular Formula:C₁₉H₂₀O₇
Molecular Weight:360.364
Hs Code.:

Synonyms:3-hydroxymethyl-2-(4-hydroxy-3-methoxyphenyl)-7-hydroxy-5-acetoxymethyl-2,3-dihydrobenzofuran

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-hydroxymethyl-2-(4-hydroxy-3-methoxyphenyl)-7-hydroxy-5-acetoxymethyl-2,3-dihydrobenzofuran

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Technology Process of 3-hydroxymethyl-2-(4-hydroxy-3-methoxyphenyl)-7-hydroxy-5-acetoxymethyl-2,3-dihydrobenzofuran

There total 11 articles about 3-hydroxymethyl-2-(4-hydroxy-3-methoxyphenyl)-7-hydroxy-5-acetoxymethyl-2,3-dihydrobenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 124662-55-1
erythro-1-(4-hydroxy-3-methoxyphenyl)-2-(2,3-dihydroxy-5-hydroxymethylphenyl)-1,3-propanediol

: 119384-68-8
3-hydroxymethyl-2-(4-hydroxy-3-methoxyphenyl)-7-hydroxy-5-acetoxymethyl-2,3-dihydrobenzofuran

Guidance literature:: With boron trifluoride diethyl etherate; In acetic acid; at 5 ℃; for 0.25h;
DOI:10.1248/cpb.37.1441

Reference yield:

: 1835-11-6
4-benzyloxy-3-methoxyacetophenone

: 119384-68-8
3-hydroxymethyl-2-(4-hydroxy-3-methoxyphenyl)-7-hydroxy-5-acetoxymethyl-2,3-dihydrobenzofuran

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / KOH / ethanol

2: 87 percent / conc. HCl / methanol; dioxane

3: 92 percent / 30percent H₂O₂, 5percent NaOH / methanol; dioxane

4: 1.) BF₃*Et₂O, 2.) NaBH₄ / 1.) benzene, 0 deg C, 2.) THF

5: 66 percent / H₂ / 10percent Pd-C / methanol

6: BF₃-Et₂O / 5 °C

With hydrogenchloride; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; boron trifluoride diethyl etherate; hydrogen; dihydrogen peroxide; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol;
DOI:10.1039/c39880000749

Reference yield:

: 119389-99-0,124662-52-8
1-(4-Benzyloxy-3-methoxy-phenyl)-2-(2,3-bis-benzyloxy-5-hydroxymethyl-phenyl)-propane-1,3-diol

: 119384-68-8
3-hydroxymethyl-2-(4-hydroxy-3-methoxyphenyl)-7-hydroxy-5-acetoxymethyl-2,3-dihydrobenzofuran

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / H₂ / 10percent Pd-C / methanol

2: BF₃-Et₂O / 5 °C

With boron trifluoride diethyl etherate; hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1039/c39880000749