N-(benzyloxycarbonyl)-L-alanyl-L-threonyl-L-alanine 2,2,2-trichloroethyl ester

Base Information

Chemical Name:N-(benzyloxycarbonyl)-L-alanyl-L-threonyl-L-alanine 2,2,2-trichloroethyl ester
CAS No.:117747-53-2
Molecular Formula:C₂₀H₂₆Cl₃N₃O₇
Molecular Weight:526.801
Hs Code.:

Synonyms:N-(benzyloxycarbonyl)-L-alanyl-L-threonyl-L-alanine 2,2,2-trichloroethyl ester

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Chemical Property of N-(benzyloxycarbonyl)-L-alanyl-L-threonyl-L-alanine 2,2,2-trichloroethyl ester

Chemical Property:

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Technology Process of N-(benzyloxycarbonyl)-L-alanyl-L-threonyl-L-alanine 2,2,2-trichloroethyl ester

There total 1 articles about N-(benzyloxycarbonyl)-L-alanyl-L-threonyl-L-alanine 2,2,2-trichloroethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1142-20-7
N-Cbz-Ala

: L-threonyl-L-alanine 2,2,2-trichloroethyl ester trifluoroacetate

: 117747-53-2
N-(benzyloxycarbonyl)-L-alanyl-L-threonyl-L-alanine 2,2,2-trichloroethyl ester

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; 1.) 0 deg C, 7 h; 2.) 25 deg C, 18 h;
DOI:10.1016/0008-6215(88)85096-1

Reference yield:

: 117747-53-2
N-(benzyloxycarbonyl)-L-alanyl-L-threonyl-L-alanine 2,2,2-trichloroethyl ester

: 117758-99-3
N-(benzyloxycarbonyl)-L-alanyl-3)>-L-threonyl-L-alanine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Drierite; 2.) tetramethylurea, 2,6-dimethylpyridine / 1.) silver triflate / 1.) CH₂Cl₂, 0 deg C, 2 h; 2.) CH₂Cl₂, 6 h, 25 deg C

2: 90 percent aq. trifluoroacetic acid, Zn powder / 4 h / 0 °C

With 2,6-dimethylpyridine; calcium sulfate; trifluoroacetic acid; tetramethylurea; zinc; silver trifluoromethanesulfonate;
DOI:10.1016/0008-6215(88)85096-1

Reference yield:

: 4291-68-3,25320-59-6,41110-63-8,67068-83-1,67773-44-8,69237-96-3,92470-93-4,93601-69-5,113829-62-2
(2R,3S,4S,5R,6R)-3,4,5-Tris-benzyloxy-2-benzyloxymethyl-6-chloro-tetrahydro-pyran

: 117747-53-2
N-(benzyloxycarbonyl)-L-alanyl-L-threonyl-L-alanine 2,2,2-trichloroethyl ester

: 117758-98-2
(S)-2-[(2S,3R)-2-((S)-2-Benzyloxycarbonylamino-propionylamino)-3-((2S,3R,4S,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-butyrylamino]-propionic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: With 2,6-dimethylpyridine; calcium sulfate; tetramethylurea; silver trifluoromethanesulfonate; Multistep reaction; 1.) CH₂Cl₂, 0 deg C, 2 h; 2.) CH₂Cl₂, 6 h, 25 deg C;
DOI:10.1016/0008-6215(88)85096-1