4-(3-chlorobenzo[b]thiophene)-2-carboxamido-3-(4-chlorophenylcarbamoyl)benzoic acid

Base Information

Chemical Name:4-(3-chlorobenzo[b]thiophene)-2-carboxamido-3-(4-chlorophenylcarbamoyl)benzoic acid
CAS No.:1374778-21-8
Molecular Formula:C₂₃H₁₄Cl₂N₂O₄S
Molecular Weight:485.347
Hs Code.:

Synonyms:4-(3-chlorobenzo[b]thiophene)-2-carboxamido-3-(4-chlorophenylcarbamoyl)benzoic acid

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Chemical Property of 4-(3-chlorobenzo[b]thiophene)-2-carboxamido-3-(4-chlorophenylcarbamoyl)benzoic acid

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Technology Process of 4-(3-chlorobenzo[b]thiophene)-2-carboxamido-3-(4-chlorophenylcarbamoyl)benzoic acid

There total 5 articles about 4-(3-chlorobenzo[b]thiophene)-2-carboxamido-3-(4-chlorophenylcarbamoyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.9%

: 21815-91-8
3-chlorobenzo[b]thiophen-2-carbonyl chloride

: 1374779-58-4
C₁₄H₁₁ClN₂O₃

: 1374778-21-8
4-(3-chlorobenzo[b]thiophene)-2-carboxamido-3-(4-chlorophenylcarbamoyl)benzoic acid

Guidance literature:: In tetrahydrofuran; for 14h; Reflux;

Reference yield:

: 4315-09-7
4-nitroisophthalic acid

: 1374778-21-8
4-(3-chlorobenzo[b]thiophene)-2-carboxamido-3-(4-chlorophenylcarbamoyl)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol

2: tetrahydrofuran / 24 h / Reflux

3: dmap / N,N-dimethyl-formamide / 10 h / 70 - 80 °C

4: tetrahydrofuran / 14 h / Reflux

With hydrogen; dmap; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 89-87-2,156617-89-9,37551-97-6
2,4-dimethylnitrobenzene

: 1374778-21-8
4-(3-chlorobenzo[b]thiophene)-2-carboxamido-3-(4-chlorophenylcarbamoyl)benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: potassium permanganate / water / 90 °C

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol

3: tetrahydrofuran / 24 h / Reflux

4: dmap / N,N-dimethyl-formamide / 10 h / 70 - 80 °C

5: tetrahydrofuran / 14 h / Reflux

With potassium permanganate; hydrogen; dmap; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;