2,4-Dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-6-carboxylic acid

Base Information

• Chemical Name: 2,4-Dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-6-carboxylic acid
• CAS No.: 77423-13-3
• Molecular Formula: C9H5 N O5
• Molecular Weight: 207.142
• Hs Code.: 2934999090
• Mol file: 77423-13-3.mol

Synonyms:2,4-Dioxo-1,4-dihydro-2H-3,1-benzoxazine-6-carboxylicacid

Chemical Property of 2,4-Dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-6-carboxylic acid

Chemical Property:

• Melting Point: >360 °C
• Refractive Index: 1.631
• PKA: 3.68±0.20(Predicted)
• PSA: 100.37000
• Density: 1.607g/cm³
• LogP: 0.17950
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

2,4-Dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-6-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-6-carboxylic acid

There total 1 articles about 2,4-Dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitroisophthalic acid (4315-09-7) → 2,4-dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-6-carboxylic acid (77423-13-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol

2: tetrahydrofuran / 24 h / Reflux

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol;

Reference yield: 84.0%

methanol (67-56-1) + 2,4-dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-6-carboxylic acid (77423-13-3) → 4-amino-3-(methoxycarbonyl)benzoic acid (41684-07-5)

Guidance literature:

With dmap; In DMF (N,N-dimethyl-formamide); at 60 ℃; for 3h;

Reference yield:

2,4-dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-6-carboxylic acid (77423-13-3) → C8H6NO4Pol

Guidance literature:

With dmap; In N,N-dimethyl-formamide; at 98 ℃; solid phase reaction;

DOI:10.1016/j.bmcl.2011.04.094

upstream raw materials:

4-nitroisophthalic acid

Downstream raw materials:

4-amino-3-(methoxycarbonyl)benzoic acid

C₁₄H₁₁ClN₂O₃

4-(3-chlorobenzo[b]thiophene)-2-carboxamido-3-(4-chlorophenylcarbamoyl)benzoic acid

N-{5-chloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-methyl-3-oxo-1,3-dihydro-2,1-benzisothiazole-5-carboxamide

Refernces