ethyl {2-oxo-5-[4-(trifluoromethoxy)phenyl]-2,3-dihydro-1H-indol-1-yl}acetate

Base Information

Chemical Name:ethyl {2-oxo-5-[4-(trifluoromethoxy)phenyl]-2,3-dihydro-1H-indol-1-yl}acetate
CAS No.:1299028-16-2
Molecular Formula:C₁₉H₁₆F₃NO₄
Molecular Weight:379.336
Hs Code.:

Synonyms:ethyl {2-oxo-5-[4-(trifluoromethoxy)phenyl]-2,3-dihydro-1H-indol-1-yl}acetate

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Chemical Property of ethyl {2-oxo-5-[4-(trifluoromethoxy)phenyl]-2,3-dihydro-1H-indol-1-yl}acetate

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Technology Process of ethyl {2-oxo-5-[4-(trifluoromethoxy)phenyl]-2,3-dihydro-1H-indol-1-yl}acetate

There total 4 articles about ethyl {2-oxo-5-[4-(trifluoromethoxy)phenyl]-2,3-dihydro-1H-indol-1-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 881608-39-5
ethyl (5-bromo-2-oxo-2,3-dihydro-1H-indol-1-yl)acetate

: 139301-27-2
4-trifluoromethoxyphenylboronic acid

: 1299028-16-2
ethyl {2-oxo-5-[4-(trifluoromethoxy)phenyl]-2,3-dihydro-1H-indol-1-yl}acetate

Guidance literature:: With water; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 150 ℃; for 0.5h; Inert atmosphere; microwave irradiation;

Reference yield:

: 87-48-9
5-Bromo-1H-indole-2,3-dione

: 1299028-16-2
ethyl {2-oxo-5-[4-(trifluoromethoxy)phenyl]-2,3-dihydro-1H-indol-1-yl}acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.42 h / 20 °C

1.2: 72 h / 20 °C

2.1: phosphorus pentachloride / N,N-dimethyl-formamide; benzene / 18 h / 80 °C / Inert atmosphere

3.1: zinc; acetic acid / 0.5 h

4.1: sodium hydrogencarbonate; water / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 150 °C / Inert atmosphere; microwave irradiation

With phosphorus pentachloride; water; sodium hydrogencarbonate; potassium carbonate; acetic acid; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; benzene;

Reference yield:

: 1299028-15-1
C₁₂H₁₀BrCl₂NO₃

: 1299028-16-2
ethyl {2-oxo-5-[4-(trifluoromethoxy)phenyl]-2,3-dihydro-1H-indol-1-yl}acetate

Guidance literature:: Multi-step reaction with 2 steps

1: zinc; acetic acid / 0.5 h

2: sodium hydrogencarbonate; water / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 150 °C / Inert atmosphere; microwave irradiation

With water; sodium hydrogencarbonate; acetic acid; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide;