di-tert-butyl (4-((6-((2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)amino)-6-oxohexyl)oxy)-1,2-phenylene)dicarbamate

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Chemical Name:di-tert-butyl (4-((6-((2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)amino)-6-oxohexyl)oxy)-1,2-phenylene)dicarbamate
CAS No.:1616779-77-1
Molecular Formula:C₂₈H₄₀N₄O₈
Molecular Weight:560.648
Hs Code.:

Synonyms:di-tert-butyl (4-((6-((2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)amino)-6-oxohexyl)oxy)-1,2-phenylene)dicarbamate

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Chemical Property of di-tert-butyl (4-((6-((2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)amino)-6-oxohexyl)oxy)-1,2-phenylene)dicarbamate

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Technology Process of di-tert-butyl (4-((6-((2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)amino)-6-oxohexyl)oxy)-1,2-phenylene)dicarbamate

There total 7 articles about di-tert-butyl (4-((6-((2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)amino)-6-oxohexyl)oxy)-1,2-phenylene)dicarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1616779-76-0
6-(3,4-bis(tert-butoxycarbonylamino)phenoxy)hexanoic acid

: 146474-00-2
N-(2-aminoethyl)maleimide trifluoroacetate

: 1616779-77-1
di-tert-butyl (4-((6-((2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)amino)-6-oxohexyl)oxy)-1,2-phenylene)dicarbamate

Guidance literature:: 6-(3,4-bis(tert-butoxycarbonylamino)phenoxy)hexanoic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.5h;

N-(2-aminoethyl)maleimide trifluoroacetate; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1039/c4cc01551g

Reference yield:

: 1616779-74-8
di-tert-butyl (4-hydroxy-1,2-phenylene)dicarbamate

: 1616779-77-1
di-tert-butyl (4-((6-((2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)amino)-6-oxohexyl)oxy)-1,2-phenylene)dicarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

2.1: lithium hydroxide / 1,4-dioxane; water / 2 h / 20 °C / Cooling with ice

3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C

3.2: 3 h / 20 °C

With potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c4cc01551g

Reference yield:

: 14273-91-7
methyl 6-iodohexanoate

: 1616779-77-1
di-tert-butyl (4-((6-((2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)amino)-6-oxohexyl)oxy)-1,2-phenylene)dicarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

2.1: lithium hydroxide / 1,4-dioxane; water / 2 h / 20 °C / Cooling with ice

3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C

3.2: 3 h / 20 °C

With potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c4cc01551g