6-(3,4-diaminophenoxy)-N-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)hexanamide

Base Information

Chemical Name:6-(3,4-diaminophenoxy)-N-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)hexanamide
CAS No.:1616779-78-2
Molecular Formula:C₁₈H₂₄N₄O₄
Molecular Weight:360.413
Hs Code.:

Synonyms:6-(3,4-diaminophenoxy)-N-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)hexanamide

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Chemical Property of 6-(3,4-diaminophenoxy)-N-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)hexanamide

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Technology Process of 6-(3,4-diaminophenoxy)-N-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)hexanamide

There total 8 articles about 6-(3,4-diaminophenoxy)-N-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)hexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1616779-77-1
di-tert-butyl (4-((6-((2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)amino)-6-oxohexyl)oxy)-1,2-phenylene)dicarbamate

: 1616779-78-2
6-(3,4-diaminophenoxy)-N-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)hexanamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h; Reagent/catalyst; Solvent;
DOI:10.1039/c4cc01551g

Reference yield:

: 1616779-75-9
methyl 6-(3,4-bis(tert-butoxycarbonylamino)phenoxy)hexanoate

: 1616779-78-2
6-(3,4-diaminophenoxy)-N-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)hexanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide / 1,4-dioxane; water / 2 h / 20 °C / Cooling with ice

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C

2.2: 3 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In 1,4-dioxane; dichloromethane; water;
DOI:10.1039/c4cc01551g

Reference yield:

: 1616779-74-8
di-tert-butyl (4-hydroxy-1,2-phenylene)dicarbamate

: 1616779-78-2
6-(3,4-diaminophenoxy)-N-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)hexanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

2.1: lithium hydroxide / 1,4-dioxane; water / 2 h / 20 °C / Cooling with ice

3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C

3.2: 3 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c4cc01551g