N-benzyloxycarbonyl-D-phenylalanyl-L-ornithyl-D-tryptophyl-L-leucine methyl ester hydrochloride

Base Information

Chemical Name:N-benzyloxycarbonyl-D-phenylalanyl-L-ornithyl-D-tryptophyl-L-leucine methyl ester hydrochloride
CAS No.:128718-83-2
Molecular Formula:C₄₀H₅₀N₆O₇*ClH
Molecular Weight:763.334
Hs Code.:

Synonyms:N-benzyloxycarbonyl-D-phenylalanyl-L-ornithyl-D-tryptophyl-L-leucine methyl ester hydrochloride

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Chemical Property of N-benzyloxycarbonyl-D-phenylalanyl-L-ornithyl-D-tryptophyl-L-leucine methyl ester hydrochloride

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Technology Process of N-benzyloxycarbonyl-D-phenylalanyl-L-ornithyl-D-tryptophyl-L-leucine methyl ester hydrochloride

There total 8 articles about N-benzyloxycarbonyl-D-phenylalanyl-L-ornithyl-D-tryptophyl-L-leucine methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.3%

: 128719-72-2
N-benzyloxycarbonyl-D-phenylalanyl-L-ornithyl(Boc)-D-tryptophyl-L-leucine methyl ester

: 128718-83-2
N-benzyloxycarbonyl-D-phenylalanyl-L-ornithyl-D-tryptophyl-L-leucine methyl ester hydrochloride

Guidance literature:: With hydrogenchloride; In acetic acid; for 0.5h; Ambient temperature;

Reference yield:

: 2448-45-5
Cbz-D-Phe

: 128718-83-2
N-benzyloxycarbonyl-D-phenylalanyl-L-ornithyl-D-tryptophyl-L-leucine methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCCI) / dimethylformamide / 4 °C

2: 81.3 percent / 3N HCl / acetic acid / 0.5 h / Ambient temperature

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 128718-83-2
N-benzyloxycarbonyl-D-phenylalanyl-L-ornithyl-D-tryptophyl-L-leucine methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 85.9 percent / dicyclohexylcarbodiimide (DCCI), 1-hydroxybenzotriazole (HOBt), Et₃N / dimethylformamide / 4 °C

2: 83.6 percent / 6N HCl, dithioethane / ethyl acetate / 1 h

3: 75 percent / Et₃N / dimethylformamide / Ambient temperature

4: H₂ / 5percent Pd/C / dimethylformamide; ethanol / 5 h

5: Et₃N, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCCI) / dimethylformamide / 4 °C

6: 81.3 percent / 3N HCl / acetic acid / 0.5 h / Ambient temperature

With hydrogenchloride; hydrogen; benzotriazol-1-ol; ethane-1,2-dithiol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide;