(2,4-dichloro-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

Base Information

• Chemical Name: (2,4-dichloro-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol
• CAS No.: 1599529-74-4
• Molecular Formula: C₂₈H₁₈Cl₂F₆N₄O
• Molecular Weight: 611.374
• Mol file: 1599529-74-4.mol

Synonyms:(2,4-dichloro-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

Chemical Property of (2,4-dichloro-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2,4-dichloro-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

There total 7 articles about (2,4-dichloro-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanone (1599524-55-6) + 6-bromo-2,4-dichloro-3-(4-(trifluoromethyl)benzyl)quinoline (1599529-49-3) → (2,4-dichloro-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol (1599529-74-4)

Guidance literature:

(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanone; 6-bromo-2,4-dichloro-3-(4-(trifluoromethyl)benzyl)quinoline; With n-butyllithium; In tetrahydrofuran; at -45 - 0 ℃; for 1.25h;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

4-Trifluoromethylbenzaldehyde (455-19-6) → (2,4-dichloro-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol (1599529-74-4)

Guidance literature:

Multi-step reaction with 4 steps

1: L-proline; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate / ethanol / 4 h / 20 °C / Inert atmosphere

2: trifluoroacetic acid / water / 3.66 h / 70 - 78 °C

3: trichlorophosphate / 6.66 h / 100 - 110 °C

4: n-butyllithium / tetrahydrofuran / 1.25 h / -45 - 0 °C

With n-butyllithium; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; trifluoroacetic acid; L-proline; trichlorophosphate; In tetrahydrofuran; ethanol; water;

Reference yield:

2-(4-(trifluoromethyl)benzyl)malonic acid (683215-73-8) → (2,4-dichloro-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol (1599529-74-4)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 6.66 h / 100 - 110 °C

2: n-butyllithium / tetrahydrofuran / 1.25 h / -45 - 0 °C

With n-butyllithium; trichlorophosphate; In tetrahydrofuran;

upstream raw materials:

4-Trifluoromethylbenzaldehyde

2,2-dimethyl-5-(4-trifluoromethyl-benzyl)-[1,3]dioxane-4,6-dione

2-(4-(trifluoromethyl)benzyl)malonic acid

6-trifluoromethylnicotinic acid

Downstream raw materials:

C₃₁H₂₄ClF₆N₅O

C₃₁H₂₄ClF₆N₅O

(2-(azetidin-1-yl)-4-chloro-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol