methyl 1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indole-3-carboxylate

Base Information

Chemical Name:methyl 1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indole-3-carboxylate
CAS No.:942217-51-8
Molecular Formula:C₂₀H₁₃F₃N₂O₂
Molecular Weight:370.331
Hs Code.:

Synonyms:methyl 1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indole-3-carboxylate

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Chemical Property of methyl 1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indole-3-carboxylate

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Technology Process of methyl 1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indole-3-carboxylate

There total 11 articles about methyl 1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1-(4-trifluoromethyl-phenyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester

: 942217-51-8
methyl 1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indole-3-carboxylate

Guidance literature:: With N-chloro-succinimide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;
DOI:10.1039/c5ra16221a

Reference yield: 85.0%

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 5619-09-0,7524-52-9,14907-27-8,26988-71-6,41222-70-2,67557-19-1,109492-62-8
methyl tryptophanate hydrochloride

: 942217-51-8
methyl 1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indole-3-carboxylate

Guidance literature:: With Cumene hydroperoxide; tetrabutylammomium bromide; In acetonitrile; at 70 ℃; for 15h; Green chemistry;
DOI:10.1016/j.cclet.2019.07.001

Reference yield:

: 73-22-3,27732-43-0,80206-30-0,27813-82-7
L-Tryptophan

: 942217-51-8
methyl 1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indole-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: acid media / Reflux

2: thionyl chloride / Cooling

3: potassium permanganate / N,N-dimethyl-formamide / Cooling

With potassium permanganate; thionyl chloride; In N,N-dimethyl-formamide;
DOI:10.3390/molecules17043969