6-hydroxy-4-methoxy-3-(3-methylbut-2-enyl)?2-(2-oxo-2-phenylethyl)benzoic acid

Base Information

Chemical Name:6-hydroxy-4-methoxy-3-(3-methylbut-2-enyl)?2-(2-oxo-2-phenylethyl)benzoic acid
CAS No.:1159593-39-1
Molecular Formula:C₂₁H₂₂O₅
Molecular Weight:354.403
Hs Code.:

Synonyms:6-hydroxy-4-methoxy-3-(3-methylbut-2-enyl)?2-(2-oxo-2-phenylethyl)benzoic acid

Suppliers and Price of 6-hydroxy-4-methoxy-3-(3-methylbut-2-enyl)?2-(2-oxo-2-phenylethyl)benzoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-hydroxy-4-methoxy-3-(3-methylbut-2-enyl)?2-(2-oxo-2-phenylethyl)benzoic acid

Chemical Property:

Purity/Quality:: ≥98% （HPLC） ^*data from raw suppliers

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Technology Process of 6-hydroxy-4-methoxy-3-(3-methylbut-2-enyl)?2-(2-oxo-2-phenylethyl)benzoic acid

There total 5 articles about 6-hydroxy-4-methoxy-3-(3-methylbut-2-enyl)?2-(2-oxo-2-phenylethyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1421341-46-9
8-hydroxy-6-methoxy-5-(3-methylbut-2-en-1-yl)-3-phenyl-1H-isochromen-1-one

: 1159593-39-1
6-hydroxy-4-methoxy-3-(3-methylbut-2-enyl)?2-(2-oxo-2-phenylethyl)benzoic acid

Guidance literature:: With water; potassium hydroxide; In ethanol; for 8h; Reflux;
DOI:10.1016/j.cclet.2014.03.027

Reference yield:

: 57749-86-7
ethyl 2,4-dimethoxy-6-methylbenzoate

: 1159593-39-1
6-hydroxy-4-methoxy-3-(3-methylbut-2-enyl)?2-(2-oxo-2-phenylethyl)benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.17 h / -78 - -74 °C / Inert atmosphere

1.2: 1.5 h / -78 °C / Inert atmosphere

2.1: aluminum (III) chloride / dichloromethane / 0.5 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 0.5 h / 20 °C

4.1: montmorillonite K₁₀ / dichloromethane / 1.5 h / 0 °C

5.1: potassium hydroxide; water / ethanol / 8 h / Reflux

With aluminum (III) chloride; water; potassium carbonate; potassium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.cclet.2014.03.027

Reference yield:

: 109480-77-5
ethyl 2,4-dimethoxy-6-(2-oxo-2-phenylethyl)benzoate

: 1159593-39-1
6-hydroxy-4-methoxy-3-(3-methylbut-2-enyl)?2-(2-oxo-2-phenylethyl)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: aluminum (III) chloride / dichloromethane / 0.5 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 0.5 h / 20 °C

3.1: montmorillonite K₁₀ / dichloromethane / 1.5 h / 0 °C

4.1: potassium hydroxide; water / ethanol / 8 h / Reflux

With aluminum (III) chloride; water; potassium carbonate; potassium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.cclet.2014.03.027