57749-86-7Relevant articles and documents
Synthesis and biological evaluation of cajanonic acid A derivatives as potential PPARγ antagonists
Guo, Bing,Hu, Chu-Jiao,Peng, Jin-Gang,Tang, Lei,Wang, Jian-Ta,Xia, Jing,Zhang, Ji-Quan,Zhu, Gao-Feng
supporting information, (2021/10/22)
Four series of cajanonic acid A (CAA) derivatives have been designed and synthesized. The newly prepared compounds have been screened for glucose consumption activity in HepG2 cell lines and PPARγ antagonistic activity in HEK293 cell lines. Compound 26g bearing a tetrahydroisoquinolinone scaffold showed the most potent PPARγ antagonistic and hypoglycemic activities. An oral glucose tolerance test (OGTT) was performed and the results further confirmed that 26g was a potent hypoglycemic agent. In addition, the possible binding modes for compound 26g in the PPARγ protein have been investigated in this study.
First total synthesis of natural products cajanolactone A and cajanonic acid A
Chen, Wen-Zhang,Fan, Ling-Ling,Xiao, Hai-Tao,Zhou, Ying,Xiao, Wan,Wang, Jian-Ta,Tang, Lei
, p. 749 - 751 (2014/06/09)
First total synthesis of cajanolactone A and cajanonic acid A has been achieved through steps of anion-anion condensations, cyclization, Williams etherification, selective demethylation, 1,3-sigmatropic rearrangement and hydrolysis. This work provides an efficient method for future cajanonic acid A derivatives synthesis.
LiCl-Promoted Pd(ii)-catalyzed ortho carbonylation of N,N- dimethylbenzylamines
Li, Hu,Cai, Gui-Xin,Shi, Zhang-Jie
, p. 10442 - 10446 (2011/01/08)
Palladium-catalyzed highly regioselective carbonylation of substituted N,N-dimethylbenzylamines with the assistance of LiCl was developed. The ortho-functionalized N,N-dimethylbenzylamine was further transformed into ortho-methyl benzoate under mild conditions. These two transformations could be combined into one pot to produce the desired product in moderate yield. Applications of this methodology to synthesize the fragments of variolaric acid were also studied.
COMPOUNDS AND COMPOSITIONS USEFUL IN THE TREATMENT OF NEOPLASIA
-
Page/Page column 49; 60-61, (2008/06/13)
There is described compounds for use in therapy, said compounds being defined by Formula (1): There is also described an anti-proliferative composition comprising one or more compounds according to Formula (1), and a method of treatment of neoplasia comprising the administration of such a compound or composition.
Total synthesis of CRM646-A and -B, two fungal glucuronides with potent heparinase inhibition activities
Wang, Ping,Zhang, Zhaojun,Yu, Biao
, p. 8884 - 8889 (2007/10/03)
CRM646-A (1) and -B (2), two fungal glucuronides with a dimeric 2,4-dihydroxy-6-alkylbenzoic acid (orcinol p-depside) aglycone showing significant heparinase and telomerase inhibition activities, were synthesized for the first time. The successful approac
Solution- and solid-phase synthesis of radicicol (monorden) and pochonin C
Barluenga, Sofia,Moulin, Emilie,Lopez, Pilar,Winssinger, Nicolas
, p. 4935 - 4952 (2007/10/03)
A modular synthesis for pochonin C and radicicol is reported. The two natural products were prepared in seven and eight steps, respectively, from three readily available fragments. Alternative syntheses of these compounds were achieved using a combination of polymer-bound reagents and solid phase reactions. The conformation of the two natural products was studied and compared by using 2D NMR spectroscopy.
Total synthesis of (±)-biphyscion
Hauser, Frank M.,Gauuan, Polivina Jolicia F.
, p. 671 - 672 (2008/02/11)
(Matrix presented) A regiospecific total synthesis of (±)-biphyscion (1) is described. A novel aspect of the plan was construction of the bianthraquinone ring system from a biphenyl intermediate through the use of a one-pot, double isobenzofuranone condensation.
Direct isocoumarin synthesis through LDA-promoted addition of acetaldehyde on orsellinate. An abrupt synthesis of 6-hydroxymellein, a fungal phytotoxin
Barbier,Devys
, p. 2757 - 2762 (2007/10/02)
The LDA-promoted addition of acetaldehyde on orsellinate gives (±) 6-hydroxymellein, a fungal phytotoxin, with a 51% yield.
Total synthesis of phleichrome, calphostin A, and calphostin D. Unusual stereoselective and stereospecific reactions in the synthesis of perylenequinones
Broka
, p. 859 - 862 (2007/10/02)
This report describes the total synthesis of phleichrome, calphostin A and calphostin D - three protein kinase C inhibitory perylenequinones. The present route affords the targets in enantiomerically pure form and represents the first successful approach
