57749-86-7

Basic information

• Product Name: Benzoic acid, 2,4-dimethoxy-6-methyl-, ethyl ester
• Synonyms: 2,4-dimethoxy-6-methyl-benzoic acid ethyl ester;2,4-O-dimethyl ethyl orsellinate;2.4-Dimethoxy-6-methylbenzoesaeureaethylester;Benzoic acid,2,4-dimethoxy-6-methyl-,ethyl ester
• CAS NO: 57749-86-7
• Molecular Formula: C12H16O4
• Molecular Weight: 224.257
• Mol File: 57749-86-7.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2,4-dimethoxy-6-methyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2,4-dimethoxy-6-methyl-, ethyl ester(57749-86-7)
• EPA Substance Registry System: Benzoic acid, 2,4-dimethoxy-6-methyl-, ethyl ester(57749-86-7)

Safety Data

• Hazardous Substances Data: 57749-86-7(Hazardous Substances Data)

Upstream product

• 311-46-6 ethyl 2-(dimethoxyphosphoryl)acetate 
• 52911-90-7 2,4-dimethoxy-6-methylpyrylium fluorosulphonate 
• 2524-37-0 ethyl orselinate 
• 74-88-4 methyl iodide 
• 39727-93-0 3,5-bis(methoxy)-N,N-dimethylbenzylamine 
• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 1258839-83-6 ethyl 2-((dimethylamino)methyl)-4,6-dimethoxybenzoate 
• 64-17-5 ethanol 
• 3686-57-5 2,4-dimethoxy-6-methylbenzoic acid 
• 13321-73-8 2-bromo-1,5-dimethoxy-3-methylbenzene 
• 152676-32-9 ethyl 3-bromo-2,4-dihydroxy-6-methylbenzoate 
• 21855-46-9 ethyl 3,5-dibromo-2,4-dihydroxy-6-methyl benzoate 
• 7149-90-8 2,4-dimethoxy-6-methyl-benzaldehyde 
• 75-03-6 ethyl iodide 

Downstream Products

• 92591-61-2 4-(2-ethoxycarbonyl-3,5-dimethoxybenzyl)-6-methyl-2H-pyran-2-one 
• 142955-98-4 ethyl 2,4-dimethoxy-6-pentadecanylbenzoate 
• 92120-76-8 3,4-dihydro-6,8-dimethoxy-3-phenyl-1H-2-benzopyran-1-one 
• 92120-77-9 3,4-dihydro-6,6',8,8'-tetramethoxy-3-phenylspiro<1H-2-benzopyran-1,3'-(3H-2-benzopyran)>-1'(4'H)-one 
• 6512-27-2 2-ethoxycarbonylmethyl-4,6-dimethoxybenzoic acid ethyl ester 
• 867367-70-2 2,4-dimethoxy-6-(2-oxo-3-phenylsulfanyl-propyl)-benzoic acid ethyl ester 
• 867367-69-9 3-Chlor-4,6-dimethoxy-2-methyl-benzoesaeure-aethylester 
• 133363-14-1 ethyl 4-methoxy-2-(methoxymethoxy)-6-methylbenzoate 
• 133363-17-4 1-Benzyloxy-3-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-propyl]-6-methoxy-8-methoxymethoxy-naphthalene-2-carbaldehyde 
• 133363-16-3 {1-Benzyloxy-3-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-propyl]-6-methoxy-8-methoxymethoxy-naphthalen-2-yl}-methanol 
• 133363-18-5 1-Benzyloxy-5-bromo-3-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-propyl]-6-methoxy-8-methoxymethoxy-naphthalene-2-carbaldehyde 
• 120461-92-9 calphostin A 

Relevant articles and documents

Synthesis and biological evaluation of cajanonic acid A derivatives as potential PPARγ antagonists

Four series of cajanonic acid A (CAA) derivatives have been designed and synthesized. The newly prepared compounds have been screened for glucose consumption activity in HepG2 cell lines and PPARγ antagonistic activity in HEK293 cell lines. Compound 26g bearing a tetrahydroisoquinolinone scaffold showed the most potent PPARγ antagonistic and hypoglycemic activities. An oral glucose tolerance test (OGTT) was performed and the results further confirmed that 26g was a potent hypoglycemic agent. In addition, the possible binding modes for compound 26g in the PPARγ protein have been investigated in this study.

LiCl-Promoted Pd(ii)-catalyzed ortho carbonylation of N,N- dimethylbenzylamines

Palladium-catalyzed highly regioselective carbonylation of substituted N,N-dimethylbenzylamines with the assistance of LiCl was developed. The ortho-functionalized N,N-dimethylbenzylamine was further transformed into ortho-methyl benzoate under mild conditions. These two transformations could be combined into one pot to produce the desired product in moderate yield. Applications of this methodology to synthesize the fragments of variolaric acid were also studied.

Solution- and solid-phase synthesis of radicicol (monorden) and pochonin C

A modular synthesis for pochonin C and radicicol is reported. The two natural products were prepared in seven and eight steps, respectively, from three readily available fragments. Alternative syntheses of these compounds were achieved using a combination of polymer-bound reagents and solid phase reactions. The conformation of the two natural products was studied and compared by using 2D NMR spectroscopy.