1-benzyloxycarbonyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-piperidine)-1-ylpropyl]-L-prolineamide

Base Information

Chemical Name:1-benzyloxycarbonyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-piperidine)-1-ylpropyl]-L-prolineamide
CAS No.:878231-90-4
Molecular Formula:C₂₉H₃₇N₃O₃
Molecular Weight:475.631
Hs Code.:

Synonyms:1-benzyloxycarbonyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-piperidine)-1-ylpropyl]-L-prolineamide

Suppliers and Price of 1-benzyloxycarbonyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-piperidine)-1-ylpropyl]-L-prolineamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-benzyloxycarbonyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-piperidine)-1-ylpropyl]-L-prolineamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-benzyloxycarbonyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-piperidine)-1-ylpropyl]-L-prolineamide

There total 4 articles about 1-benzyloxycarbonyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-piperidine)-1-ylpropyl]-L-prolineamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 252002-18-9
3-spiro[2,3-dihydro-1H-indene-1,4'-piperidine]-1-ylpropane-1-amine

: 1148-11-4
N-Benzyloxycarbonyl-L-proline

: 878231-90-4
1-benzyloxycarbonyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-piperidine)-1-ylpropyl]-L-prolineamide

Guidance literature:: N-Benzyloxycarbonyl-L-proline; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In chloroform; at 20 ℃; for 0.0833333h;

3-spiro[2,3-dihydro-1H-indene-1,4'-piperidine]-1-ylpropane-1-amine; In chloroform; at 20 ℃; for 0.5h;
DOI:10.1021/jm0509851

Reference yield:

: 878231-75-5
C₂₄H₂₄N₂O₂

: 878231-90-4
1-benzyloxycarbonyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-piperidine)-1-ylpropyl]-L-prolineamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / H₂ / Pd(OH)2 / methanol; tetrahydrofuran / 1 h

2.1: 91.3 percent / hydrazine monohydrate / ethanol; CHCl₃ / 1 h / Heating

3.1: HOBT; WSC / CHCl₃ / 0.08 h / 20 °C

3.2: 73 percent / CHCl₃ / 0.5 h / 20 °C

With hydrogen; benzotriazol-1-ol; hydrazine hydrate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium dihydroxide; In tetrahydrofuran; methanol; ethanol; chloroform;
DOI:10.1021/jm0509851

Reference yield:

: 33042-66-9
spiro[indene-1,4'-piperidine]

: 878231-90-4
1-benzyloxycarbonyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-piperidine)-1-ylpropyl]-L-prolineamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 52 percent / potassium carbonate / dimethylformamide / 1 h / 60 °C

2.1: 100 percent / H₂ / Pd(OH)2 / methanol; tetrahydrofuran / 1 h

3.1: 91.3 percent / hydrazine monohydrate / ethanol; CHCl₃ / 1 h / Heating

4.1: HOBT; WSC / CHCl₃ / 0.08 h / 20 °C

4.2: 73 percent / CHCl₃ / 0.5 h / 20 °C

With hydrogen; potassium carbonate; benzotriazol-1-ol; hydrazine hydrate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium dihydroxide; In tetrahydrofuran; methanol; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm0509851