Technology Process of N-{5-[4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-2-enoyl]-2,3-dihydro-1H-inden-1-yl}propanamide
There total 5 articles about N-{5-[4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-2-enoyl]-2,3-dihydro-1H-inden-1-yl}propanamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium hydride;
In
tetrahydrofuran;
for 8h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydroxylamine hydrochloride; sodium acetate / methanol / 20 h / 20 °C
2.1: sodium tetrahydroborate / nickel(II) chloride hexahydrate / 1,4-dioxane; methanol / 1 h / -20 °C
2.2: 0.5 h
3.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / -75 °C / Inert atmosphere
3.2: 1 h / Inert atmosphere
4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
4.3: 8 h / 20 °C
5.1: lithium hydride / tetrahydrofuran / 8 h / Reflux
With
sodium tetrahydroborate; n-butyllithium; hydroxylamine hydrochloride; sodium acetate; lithium hydride; trifluoroacetic acid;
nickel(II) chloride hexahydrate;
In
tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium tetrahydroborate / nickel(II) chloride hexahydrate / 1,4-dioxane; methanol / 1 h / -20 °C
1.2: 0.5 h
2.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / -75 °C / Inert atmosphere
2.2: 1 h / Inert atmosphere
3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
3.3: 8 h / 20 °C
4.1: lithium hydride / tetrahydrofuran / 8 h / Reflux
With
sodium tetrahydroborate; n-butyllithium; lithium hydride; trifluoroacetic acid;
nickel(II) chloride hexahydrate;
In
tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane;