185122-63-8

Usage

Uses

Used in Organic Synthesis:
5-Bromo-1-indanone oxime is employed as a key intermediate in the synthesis of various organic compounds. Its unique structure and reactivity make it a preferred choice for the development of new chemical entities.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-Bromo-1-indanone oxime is used as a building block for the synthesis of biologically active compounds. Its oxime functionality and other structural features contribute to the creation of potential drug candidates.
Used in Research:
5-Bromo-1-indanone oxime is utilized as a reagent in academic and industrial research settings. It aids in the preparation of complex organic molecules and the study of organic reaction mechanisms, furthering the understanding of chemical processes and the development of novel synthetic routes.
Used in the Study of Organic Reaction Mechanisms:
5-Bromo-1-indanone oxime is applied in the investigation of reaction mechanisms in organic chemistry. Its participation in various chemical reactions provides insights into the underlying processes and helps in optimizing reaction conditions for better yields and selectivity.

Upstream product

• 34598-49-7 5-Bromo-1-indanone 
• 31736-73-9 4-bromophenyl 2-chloroethyl ketone 
• 108-86-1 bromobenzene 

Downstream Products

• 1199829-02-1 ethyl 1-((1-(benzyloxycarbonylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate 
• 1199828-95-9 N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-1-yl)-2-methoxybenzenesulfonamide 
• 1199829-04-3 benzyl 5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-1-ylcarbamate 
• 1199828-99-3 methyl 1-(benzyloxycarbonylamino)-2,3-dihydro-1H-indene-5-carboxylate 
• 1251457-86-9 benzyl 5-(chloromethyl)-2,3-dihydro-1H-inden-1-ylcarbamate 
• 1199829-00-9 benzyl 5-(hydroxymethyl)-2,3-dihydro-1H-inden-1-ylcarbamate 
• 1199828-97-1 benzyl 5-bromo-2,3-dihydro-1H-inden-1-ylcarbamate 
• 1555862-60-6 5-[3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl]indan-1-amine 
• 1187512-62-4 N-[5-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)-2,4-dihydropyrrol-5-yl]indan-1-yl]acetamide 
• 1187196-68-4 tert-butyl N-[5-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)-2.4-dihydropyrrol-5-yl]indan-1-yl]carbamate 
• 1455457-34-7 N-(5-{3-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl}-2,3-dihydro-1H-inden-1-yl)propanamide 
• 1221771-61-4 N-(5-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-2,3-dihydro-1H-inden-1-yl)propanamide 
• 1338926-70-7 N-{5-[4,4,4-trifluoro-3-(nitromethyl)-3-(3,4,5-trichloro-phenyl)butanoyl]-2,3-dihydro-1H-inden-1-yl}propanamide 
• 1338926-78-5 5-(3-bromo-4-fluorophenyl)-3-(3,4,5-trichloro-phenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrole 

Relevant academic research and scientific papers

Deconstructive Oxygenation of Unstrained Cycloalkanamines

A deconstructive oxygenation of unstrained primary cycloalkanamines has been developed for the first time using an auto-oxidative aromatization promoted C(sp3)?C(sp3) bond cleavage strategy. This metal-free method involves the substitution reaction of cycloalkanamines with hydrazonyl chlorides and subsequent auto-oxidative annulation to in situ generate pre-aromatics, followed by N-radical-promoted ring-opening and further oxygenation by 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and m-cholorperoxybenzoic acid (mCPBA). Consequently, a series of 1,2,4-triazole-containing acyclic carbonyl compounds were efficiently produced. This protocol features a one-pot operation, mild reaction conditions, high regioselectivity and ring-opening efficiency, broad substrate scope, and is compatible with alkaloids, osamines, and peptides, as well as steroids.

Substituted ring compound and its method and use thereof

The invention provides a substituted cyclic compound as well as a use method and application thereof. The compound is a compound as shown in a formula (I) or stereoisomers, stereomers, tautomers, nitric oxides, solvates, metabolites and pharmaceutically acceptable salts or prodrugs of the compound as shown in the formula (I). The invention further provides a medicament composition containing the compound. The compound and the medicament composition are capable of regulating the activity of protein kinase in a biological sample body and are used for protecting, treating or relieving proliferative diseases of patients. The formula (I) is as shown in the specification.

ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

A compound of formula (I): wherein the substituents are as defined in the description. Medicinal products containing the same which are useful in treating or preventing pathologies which are the result of activation of the RhoA/ROCK pathway and phosphorylation of the myosin light chain.

Highly enantioselective [3+2] coupling of cyclic enamides with quinone monoimines promoted by a chiral phosphoric acid

Enantioselective [3+2] coupling of cyclic enamides with quinone monoimines was realised using a chiral phosphoric acid as a catalyst. This transformation allowed for the synthesis of highly enantioenriched polycyclic 2,3-dihydrobenzofurans (up to 99.9% ee). The absolute configuration of one product was determined by an X-ray crystal structural analysis. We also found a possible mechanism for this reaction.

METHODS OF PEST CONTROL IN SOYBEAN

The invention provides methods comprising applying to a crop of soybean plants, the locus thereof, or propagation material thereof, a compound of formula (I) wherein -B1-B2-B3- is -C=N-O-, -C=N-CH2- or -N-CH2-CH2-; Y1, Y2 and Y3 are independently CH or nitrogen; wherein no more than two of Y1, Y2 and Y3 are nitrogen and wherein Y2 and Y3 are not both nitrogen; R9 is C1-C4alkyl, C1-C4haloalkyl, C1-C4alkyl-O-CH2-, C1-C4haloalkyl-O-CH2-,C3-C6cycloalkyl, C3-C6cycloalkyl-CH2-, C1-C4alkyl-S-CH2-, C1-C4alkyl-S(O)-CH2-, or C1-C4alkyl-S(O2)-CH2-; X2 is C-X6 or nitrogen; X1, X3 and X6 are independently hydrogen, halogen or trihalomethyl, wherein at least two of X1, X3 and X6 are not hydrogen; X4 is trifluoromethyl, difluoromethyl or chlorodifluoromethyl. Preferably the methods are for control of stinkbugs, in particular from the genus Euschistus and in particular the species Euschistus heros.

METHODS OF CONTROLLING INSECTS

The present invention provides a method comprising applying to a crop of cotton plants, the locus thereof, or propagation material thereof, a compound of formula (I) wherein -B1-B2-B3-is -C=N-O-, -C=N-CH2-, or -

METHODS OF CONTROLLING INSECTS

The present invention provides a method comprising applying to a crop of rice plants, the locus thereof, or propagation material thereof, a compound of formula (I) wherein -B1-Β2-Β3- is -C=N-O-, -C=N-CH2-, or -N

METHODS OF SOIL PEST CONTROL

The present invention provides a method of controlling and/or preventing soil-dwelling pests in useful plants comprising applying to the locus of the useful plant or treating propagation material thereof, preferably a seed, with a compound of formula (I),

METHODS OF CONTROLLING INSECTS

The present invention provides provides a method for controlling and/or preventing insects from the genus of Plutella in useful plants, comprising applying to a crop of useful plants, the locus thereof, or propagation material thereof, a compound of formu

SUBSTITUTED CYCLIC COMPOUNDS AND METHODS OF USE

The present invention provides novel substituted alkynyl compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.