N-[2-[4-phenyl-1-piperazinyl]ethyl]-N-(2-pyridyl)-1-naphthalene-carboxamide

Base Information

Chemical Name:N-[2-[4-phenyl-1-piperazinyl]ethyl]-N-(2-pyridyl)-1-naphthalene-carboxamide
CAS No.:1391870-75-9
Molecular Formula:C₂₈H₂₈N₄O
Molecular Weight:436.557
Hs Code.:

Synonyms:N-[2-[4-phenyl-1-piperazinyl]ethyl]-N-(2-pyridyl)-1-naphthalene-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-[4-phenyl-1-piperazinyl]ethyl]-N-(2-pyridyl)-1-naphthalene-carboxamide

Chemical Property:

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Technology Process of N-[2-[4-phenyl-1-piperazinyl]ethyl]-N-(2-pyridyl)-1-naphthalene-carboxamide

There total 3 articles about N-[2-[4-phenyl-1-piperazinyl]ethyl]-N-(2-pyridyl)-1-naphthalene-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 2-(4-phenyl-1-piperazinyl)-N-(pyridin-2-yl)ethylamine

: 879-18-5
naphthalene-1-carbonic acid chloride

: 1391870-75-9
N-[2-[4-phenyl-1-piperazinyl]ethyl]-N-(2-pyridyl)-1-naphthalene-carboxamide

Guidance literature:: With triethylamine; In ethyl acetate; at 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2012.05.119

Reference yield:

: 328276-50-2
4-phenyl-1-(2-pyridinylaminocarbonyl)methylpiperazine

: 1391870-75-9
N-[2-[4-phenyl-1-piperazinyl]ethyl]-N-(2-pyridyl)-1-naphthalene-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / diethyl ether / 1.08 h / 0 °C / Reflux

2: triethylamine / ethyl acetate / 2 h / 20 °C

With lithium aluminium tetrahydride; triethylamine; In diethyl ether; ethyl acetate;
DOI:10.1016/j.bmcl.2012.05.119

Reference yield:

: 504-29-0
2-aminopyridine

: 1391870-75-9
N-[2-[4-phenyl-1-piperazinyl]ethyl]-N-(2-pyridyl)-1-naphthalene-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / 1,4-dioxane / 20 °C

2: triethylamine / 1,4-dioxane / 20 °C / Reflux

3: lithium aluminium tetrahydride / diethyl ether / 1.08 h / 0 °C / Reflux

4: triethylamine / ethyl acetate / 2 h / 20 °C

With lithium aluminium tetrahydride; triethylamine; In 1,4-dioxane; diethyl ether; ethyl acetate;
DOI:10.1016/j.bmcl.2012.05.119