328276-50-2Relevant academic research and scientific papers
Structural Insights into 5-HT1A/D4 Selectivity of WAY-100635 Analogues: Molecular Modeling, Synthesis, and in Vitro Binding
Dilly, Sébastien,Liégeois, Jean-Fran?ois
, p. 1324 - 1331 (2016)
The resurgence of interest in 5-HT1A receptors as a therapeutic target requires the existence of highly selective 5-HT1A ligands. To date, WAY-100635 has been the prototypical antagonist of these receptors. However, this compound als
Moderate chemical modifications of WAY-100635 improve the selectivity for 5-HT1A versus D4 receptors
Mangin, Floriane,Dilly, Sebastien,Joly, Benoit,Scuvee-Moreau, Jacqueline,Evans, Jon,Setola, Vincent,Roth, Bryan L.,Liegeois, Jean-Francois
supporting information; experimental part, p. 4550 - 4554 (2012/08/08)
The selectivity for 5-HT1A versus D4 receptors is significantly increased when the basic side chain of WAY-100635 is replaced by a 4-phenylpiperazine (3e) or a 4-phenyl-1,2,3,6-tetrahydropyridine moiety (3i). The 4-phenyl-1,2,3,6-tet
