(S)-N-((R)-2-(3-bromophenyl)-1-(tert-butyldiphenylsilyloxy)propan-2-yl)-2-methylpropane-2-sulfinamide

Base Information

• Chemical Name: (S)-N-((R)-2-(3-bromophenyl)-1-(tert-butyldiphenylsilyloxy)propan-2-yl)-2-methylpropane-2-sulfinamide
• CAS No.: 1394137-79-1
• Molecular Formula: C₂₉H₃₈BrNO₂SSi
• Molecular Weight: 572.682

Synonyms:(S)-N-((R)-2-(3-bromophenyl)-1-(tert-butyldiphenylsilyloxy)propan-2-yl)-2-methylpropane-2-sulfinamide

Chemical Property of (S)-N-((R)-2-(3-bromophenyl)-1-(tert-butyldiphenylsilyloxy)propan-2-yl)-2-methylpropane-2-sulfinamide

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Technology Process of (S)-N-((R)-2-(3-bromophenyl)-1-(tert-butyldiphenylsilyloxy)propan-2-yl)-2-methylpropane-2-sulfinamide

There total 1 articles about (S)-N-((R)-2-(3-bromophenyl)-1-(tert-butyldiphenylsilyloxy)propan-2-yl)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-(1-(3-bromophenyl)-2-(tert-butyldiphenylsilyloxy)ethylidene)-2-methylpropane-2-sulfinamide + methylmagnesium bromide (75-16-1) → (S)-N-((R)-2-(3-bromophenyl)-1-(tert-butyldiphenylsilyloxy)propan-2-yl)-2-methylpropane-2-sulfinamide (1394137-79-1)

Guidance literature:

In diethyl ether; dichloromethane; at 0 - 20 ℃; for 0.333333h; optical yield given as %de; Inert atmosphere;

DOI:10.1039/c2ob25845e

Reference yield: 88.0%

(S)-N-((R)-2-(3-bromophenyl)-1-(tert-butyldiphenylsilyloxy)propan-2-yl)-2-methylpropane-2-sulfinamide (1394137-79-1) → (S)-N-((R)-2-(3-bromophenyl)-1-hydroxypropan-2-yl)-2-methylpropane-2-sulfinamide

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1039/c2ob25845e

Reference yield: 73.0%

(S)-N-((R)-2-(3-bromophenyl)-1-(tert-butyldiphenylsilyloxy)propan-2-yl)-2-methylpropane-2-sulfinamide (1394137-79-1) → (R)-2-(3-bromophenyl)-1-(tert-butyldiphenylsilyloxy)propan-2-amine (1394137-69-9)

Guidance literature:

With hydrogenchloride; In methanol; diethyl ether; at 20 ℃; for 2h;

DOI:10.1039/c2ob25845e

upstream raw materials:

methylmagnesium bromide

Downstream raw materials:

(R)-2-(3-bromophenyl)-1-(tert-butyldiphenylsilyloxy)propan-2-amine

(2R)-2-amino-2-(3-bromophenyl)-propan-1-ol

(R)-tert-butyl N-[1-(3-bromophenyl)-2-hydroxy-1-methylethyl]carbamate

(R)-methyl 2-(3-bromophenyl)-2-(tert-butoxycarbonylamino)propanoate

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