(E)-3-(4-phenylthiophen-2-yl)-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-one

Base Information

Chemical Name:(E)-3-(4-phenylthiophen-2-yl)-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-one
CAS No.:1410102-56-5
Molecular Formula:C₂₀H₁₃F₃OS
Molecular Weight:358.384
Hs Code.:

Synonyms:(E)-3-(4-phenylthiophen-2-yl)-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-one

Suppliers and Price of (E)-3-(4-phenylthiophen-2-yl)-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-3-(4-phenylthiophen-2-yl)-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-one

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Technology Process of (E)-3-(4-phenylthiophen-2-yl)-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-one

There total 1 articles about (E)-3-(4-phenylthiophen-2-yl)-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 26170-87-6
4-phenylthiophene-2-carbaldehyde

: 709-63-7
1-(4-trifluoromethylphenyl)ethanone

: 1410102-56-5
(E)-3-(4-phenylthiophen-2-yl)-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-one

Guidance literature:: With sodium hydroxide; In ethanol; water; at 20 ℃; for 1h;
DOI:10.1021/jm3010477

Reference yield: 93.0%

: 1410102-56-5
(E)-3-(4-phenylthiophen-2-yl)-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-one

: 105-53-3
diethyl malonate

: 1221964-29-9
diethyl 2-(3-(4-chlorophenyl)-3-oxo-1-phenylpropyl)malonate

Guidance literature:: With magnesium oxide; In toluene; at 20 ℃; for 2h;
DOI:10.1021/jm3010477

Reference yield:

: 1410102-56-5
(E)-3-(4-phenylthiophen-2-yl)-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-one

: 1221964-27-7
2-(3-Oxo-1-(4-phenylthiophen-2-yl)-3-(4-(trifluoromethyl)phenyl)propyl)-malonic acid

Guidance literature:: Multi-step reaction with 2 steps

1: magnesium oxide / toluene / 2 h / 20 °C

2: sodium hydroxide / ethanol; water / 4 h / Reflux

With magnesium oxide; sodium hydroxide; In ethanol; water; toluene; 1: |Michael Addition;
DOI:10.1021/jm3010477