3-(N-tert-butoxycarbonylamino)-5-aminobenzoic acid ethyl ester

Base Information

• Chemical Name: 3-(N-tert-butoxycarbonylamino)-5-aminobenzoic acid ethyl ester
• CAS No.: 341925-61-9
• Molecular Formula: C₁₄H₂₀N₂O₄
• Molecular Weight: 280.324
• Mol file: 341925-61-9.mol

Synonyms:3-(N-tert-butoxycarbonylamino)-5-aminobenzoic acid ethyl ester

Chemical Property of 3-(N-tert-butoxycarbonylamino)-5-aminobenzoic acid ethyl ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(N-tert-butoxycarbonylamino)-5-aminobenzoic acid ethyl ester

There total 2 articles about 3-(N-tert-butoxycarbonylamino)-5-aminobenzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

di-tert-butyl dicarbonate (24424-99-5) + 3,5-diaminobenzoic acid ethyl ester (1949-51-5) → 3-(N-tert-butoxycarbonylamino)-5-aminobenzoic acid ethyl ester (341925-61-9)

Guidance literature:

With triethylamine; In 1,4-dioxane; water; at 0 - 20 ℃; for 11h;

DOI:10.1021/jo001079t

Reference yield:

3.5-diaminobenzoic acid (535-87-5) → 3-(N-tert-butoxycarbonylamino)-5-aminobenzoic acid ethyl ester (341925-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / SOCl₂ / 24 h / Heating

2: 83 percent / Et₃N / H₂O; dioxane / 11 h / 0 - 20 °C

With thionyl chloride; triethylamine; In 1,4-dioxane; water;

DOI:10.1021/jo001079t

Reference yield: 93.0%

1-hexadecylcarboxylic acid (57-10-3) + 3-(N-tert-butoxycarbonylamino)-5-aminobenzoic acid ethyl ester (341925-61-9) → 3-(N-tert-butoxycarbonylamino)-5-(N'-hexadecanoylamino)benzoic acid ethyl ester (341925-76-6)

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In chloroform; at 0 - 20 ℃; for 21h;

DOI:10.1021/jo001079t

upstream raw materials:

di-tert-butyl dicarbonate

3,5-diaminobenzoic acid ethyl ester

3.5-diaminobenzoic acid

Downstream raw materials:

3-(N-tert-butoxycarbonylamino)-5-(N'-decanoylamino)benzoic acid ethyl ester

3-(N-tert-butoxycarbonylamino)-5-(N'-hexadecanoylamino)benzoic acid ethyl ester

3-[N-(N-tert-butoxycarbonyl-L-alanyl)amino]-5-(N'-decanoylamino)benzoic acid

3-[N-(N-tert-butoxycarbonyl-L-alanyl)amino]-5-(N'-hexadecanoylamino)benzoic acid